Clinicoradiologic response of neurologic tuberculous mass lesions in children treated with thalidomide

The Pediatric Infectious Disease Journal
Ronald van ToornJohan F Schoeman

Abstract

Neurologic tuberculous pseudoabscesses that clinically progress despite conventional antituberculosis therapy may be responsive to adjuvant thalidomide, a potent tumor necrosis factor-α inhibitor. In this study, the addition of thalidomide provided substantial clinical benefit in the majority of patients, and magnetic resonance imaging evolution of lesions from early-stage "T2 bright" with edema to "T2 black" represented a marker of cure.

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Citations

Jan 16, 2019·Journal of Leukocyte Biology·Angharad Grace DavisRobert J Wilkinson
Dec 28, 2018·The Journal of Infectious Diseases·Daniel J FrankZaid Tanvir
Mar 2, 2018·Current Treatment Options in Neurology·Angharad DavisRobert J Wilkinson
Sep 24, 2020·Expert Review of Respiratory Medicine·James A SeddonH Simon Schaaf
Feb 9, 2017·Journal of Neuroinflammation·Catherine W M OngJon S Friedland
May 5, 2020·Wellcome Open Research·Suzaan MaraisUNKNOWN Tuberculous Meningitis International Research Consortium
Sep 7, 2018·Journal of the Pediatric Infectious Diseases Society·Alexandra Duque-SilvaPennan M Barry
Mar 3, 2020·Wellcome Open Research·James A SeddonUNKNOWN Tuberculous Meningitis International Research Consortium
Dec 8, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ronald van ToornJohan F Schoeman
Apr 16, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Regan S SolomonsRonald van Toorn

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