Clinoenstatite coatings have high bonding strength, bioactive ion release, and osteoimmunomodulatory effects that enhance in vivo osseointegration

Biomaterials
Chengtie WuYin Xiao

Abstract

A number of coating materials have been developed over past two decades seeking to improve the osseointegration of orthopedic metal implants. Despite the many candidate materials trialed, their low rate of translation into clinical applications suggests there is room for improving the current strategies for their development. We therefore propose that the ideal coating material(s) should possess the following three properties: (i) high bonding strength, (ii) release of functional ions, and (iii) favourable osteoimmunomodulatory effects. To test this proposal, we developed clinoenstatite (CLT, MgSiO3), which as a coating material has high bonding strength, cytocompability and immunomodulatory effects that are favourable for in vivo osteogenesis. The bonding strength of CLT coatings was 50.1 ± 3.2 MPa, more than twice that of hydroxyapatite (HA) coatings, at 23.5 ± 3.5 MPa. CLT coatings released Mg and Si ions, and compared to HA coatings, induced an immunomodulation more conducive for osseointegration, demonstrated by downregurelation of pro-inflammatory cytokines, enhancement of osteogenesis, and inhibition of osteoclastogenesis. In vivo studies demonstrated that CLT coatings improved osseointegration with host bone, as shown b...Continue Reading

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Citations

Sep 16, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Settimio PacelliArghya Paul
Jan 22, 2017·Journal of Materials Science. Materials in Medicine·Rodney Marcelo do NascimentoNilson Cristino da Cruz
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Feb 11, 2021·Advanced Materials·Jinhua LiZhen Gu
Apr 24, 2021·Journal of Colloid and Interface Science·Monica TonelliMassimo Bonini
Aug 22, 2021·Acta Biomaterialia·Kai ZhengAldo R Boccaccini

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