Cloaked Exosomes: Biocompatible, Durable, and Degradable Encapsulation

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Sumit KumarYoon-Kyoung Cho

Abstract

Exosomes-nanosized extracellular vesicles (EVs) naturally secreted from cells-have emerged as promising biomarkers and potential therapeutic vehicles, but methods to manipulate them for engineering purposes remain elusive. Among the technical obstacles are the small size and surface complexity of exosomes and the complex processing steps required, which reduce the biocompatibility of currently available methods. The encapsulation of exosomes with a nanofilm of supramolecular complexes of ferric ions (Fe3+ ) and tannic acid is demonstrated here. The resulting natural polyphenol, ≈10 nm thick, protects exosomes from external aggressors such as UV-C irradiation or heat and is controllably degraded on demand. Furthermore, gold nanoparticles can be covalently attached for single-exosome level visualization. To fully exploit their therapeutic potential, chemotherapeutic drug-loaded EVs are functionalized to achieve the targeted, selective killing of cancer cells preferentially over normal cells. This nanofilm not only preserves the native size and chemical makeup of the intrinsic exosomes, but also confers new capabilities for efficient tumor targeting and pH-controlled release of drugs. Demonstrating a scalable method to produce bio...Continue Reading

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Citations

Aug 6, 2020·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Davod JafariAli Samadikuchaksaraei
Mar 25, 2020·Science Advances·Ziyi GuoKang Liang
Oct 9, 2020·Chemistry, an Asian Journal·Zejun JiangJianping Li
Jan 21, 2021·International Journal of Nanomedicine·Kai ChenXin Wang
Nov 19, 2019·Biomacromolecules·Stefanie L BakerKrzysztof Matyjaszewski
Oct 30, 2020·International Journal of Nanomedicine·Victor C Kok, Cheng-Chia Yu
Mar 2, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Benke LiRuikang Tang
Mar 22, 2021·Molecular Neurobiology·Nashmin FayaziRezvan Najafi
Jun 18, 2021·ACS Applied Materials & Interfaces·Divakara Ssm UppuYoon-Kyoung Cho
Jun 20, 2021·Advanced Science·Jiating XuYujie Fu
Jun 18, 2021·Frontiers in Molecular Biosciences·Lanxiang HuangFubing Wang
Nov 11, 2019·ACS Biomaterials Science & Engineering·Junling GuoHirotaka Ejima

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