Clobazam as an add-on in the management of refractory epilepsy

The Cochrane Database of Systematic Reviews
B Michael, Anthony G Marson

Abstract

Epilepsy effects approximately 1% of the population, with up to 30% of patients continuing to have seizures despite antiepileptic drug treatment. To assess the efficacy and tolerability of clobazam when used as an add-on therapy for patients with refractory partial onset or generalised onset seizures. We searched the following on 22nd March 2007: (a) The Cochrane Epilepsy Group Specialised Register; (b) The Cochrane Central Register of Controlled Trials (CENTRAL); (c) MEDLINE; (d) EMBASE; (e) Database of Abstracts of Reviews of Effectiveness (DARE); (f) American College of Physicians Journals; (g) BIOSIS. Randomised trials of add-on clobazam, with adequate methods of allocation concealment, recruiting patients with drug refractory partial or generalised onset seizures, with a minimum treatment period of eight weeks. Two review authors independently selected trials for inclusion and extracted relevant data. The following outcomes were assessed: 50% or greater reduction in seizures; seizure freedom; treatment withdrawal and adverse effects. Four cross-over studies, representing 196 participants, were included. However, due to significant methodological heterogeneity and differences in outcome measures it was not possible to summa...Continue Reading

References

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Oct 27, 2009·Neurologic Clinics·Linda J Stephen, Martin J Brodie
Apr 27, 2010·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Karl O NakkenFrans Brockmeier
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Oct 23, 2019·The Cochrane Database of Systematic Reviews·Rebecca BresnahanAnthony G Marson
Sep 4, 2015·The Cochrane Database of Systematic Reviews·Cerian F JacksonMichael Kerr

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