Clock drawing performance and brain morphology in mild cognitive impairment and Alzheimer's disease

Brain and Cognition
Philipp A ThomannJohannes Schröder

Abstract

The Clock Drawing Test (CDT) is a widely used instrument in the neuropsychological assessment of Alzheimer's disease (AD). As CDT performance necessitates several cognitive functions (e.g., visuospatial and constructional abilities, executive functioning), an interaction of multiple brain regions is likely. Fifty-one subjects with mild cognitive impairment, 23 with AD and 15 healthy controls underwent high-resolution magnetic resonance imaging. Optimized voxel-based morphometry (VBM) was performed to investigate the putative association between CDT performance and gray matter (GM) density throughout the entire brain. In the first step of analysis (p<.001, uncorrected), VBM revealed a reduced GM density in numerous cortical (temporal lobe, frontal lobe, parietal lobe, cerebellum) and subcortical (thalamus, basal ganglia) brain regions to be associated with poorer CDT performance. When corrected for multiple comparisons (p<.01), the associations remained significant predominantly in the left temporal and--less pronounced--the right temporal lobe. VBM demonstrated CDT performance to depend on the integrity of widely distributed cortical and subcortical areas in both brain hemispheres with accentuation in the left-sided temporal lo...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Aug 1, 1989·Journal of the American Geriatrics Society·T SunderlandJ H Grafman
Aug 1, 1989·Journal of the American Geriatrics Society·G P Wolf-KleinM S Brod
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Sep 14, 2001·Psychiatry and Clinical Neurosciences·Y KitabayashiK Fukui
Jun 24, 2004·Dementia and Geriatric Cognitive Disorders·Sayaka YamamotoAkihisa Iguchi
Apr 2, 2005·Dementia and Geriatric Cognitive Disorders·Yasuhiro NagahamaMinoru Matsuda
Nov 3, 2005·The American Journal of Psychiatry·Peter SchönknechtJohannes Schröder

❮ Previous
Next ❯

Citations

Oct 17, 2012·Brain Imaging and Behavior·Kwangsik NhoUNKNOWN Alzheimer’s Disease Neuroimaging Initiative--ADNI
Aug 21, 2009·International Psychogeriatrics·Lena EhrekeSteffi G Riedel-Heller
Feb 8, 2013·Journal of Clinical and Experimental Neuropsychology·Rebecca J MelroseDavid L Sultzer
Sep 22, 2015·Frontiers in Neuroscience·Christian SalvatoreUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 16, 2010·Psychiatry Research·Robert PerneczkyPeter Häussermann
Sep 24, 2015·Applied Neuropsychology. Adult·Samrah AhmedDavid J Libon
May 27, 2015·Clinical Neurology and Neurosurgery·Fabricio Ferreira de OliveiraMarilia Cardoso Smith
Apr 23, 2016·Journal of Alzheimer's Disease : JAD·Luigi Trojano, Guido Gainotti
Dec 7, 2010·Ageing Research Reviews·Huijie LiTing Zhou
Jun 11, 2011·Neuro-degenerative Diseases·Kristian Steen FrederiksenGunhild Waldemar
Nov 20, 2016·Acta Ophthalmologica·Yael KusneGholam A Peyman
Oct 30, 2018·International Journal of Geriatric Psychiatry·Thitiporn SupasitthumrongKenneth Shulman
Jul 20, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Dusan HirjakPhilipp A Thomann
Nov 7, 2008·Expert Review of Neurotherapeutics·Geraldo F BusattoMarcus V Zanetti
Feb 26, 2019·Frontiers in Human Neuroscience·Natasha A TalwarTom A Schweizer
Feb 11, 2012·Neuroscience Letters·Ulrich SeidlPhilipp A Thomann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.