Clocking In Time to Gate Memory Processes: The Circadian Clock Is Part of the Ins and Outs of Memory

Neural Plasticity
Oliver RawashdehErik Maronde

Abstract

Learning, memory consolidation, and retrieval are processes known to be modulated by the circadian (circa: about; dies: day) system. The circadian regulation of memory performance is evolutionarily conserved, independent of the type and complexity of the learning paradigm tested, and not specific to crepuscular, nocturnal, or diurnal organisms. In mammals, long-term memory (LTM) formation is tightly coupled to de novo gene expression of plasticity-related proteins and posttranslational modifications and relies on intact cAMP/protein kinase A (PKA)/protein kinase C (PKC)/mitogen-activated protein kinase (MAPK)/cyclic adenosine monophosphate response element-binding protein (CREB) signaling. These memory-essential signaling components cycle rhythmically in the hippocampus across the day and night and are clearly molded by an intricate interplay between the circadian system and memory. Important components of the circadian timing mechanism and its plasticity are members of the Period clock gene family (Per1, Per2). Interestingly, Per1 is rhythmically expressed in mouse hippocampus. Observations suggest important and largely unexplored roles of the clock gene protein PER1 in synaptic plasticity and in the daytime-dependent modulati...Continue Reading

References

Jun 1, 1975·Behavioral Biology·R A Wansley, F A Holloway
Jun 1, 1985·Physiology & Behavior·M FeketeD de Wied
Mar 1, 1974·Journal of Comparative and Physiological Psychology·A A BuergerC E Rocha-Miranda
Jun 1, 1974·Journal of Comparative and Physiological Psychology·D Gaffan
Jan 1, 1968·The American Journal of Physiology·L E SchevingJ E Pauly
Mar 6, 1981·Science·W N Tapp, F A Holloway
Sep 6, 1996·Science·B J KnowltonL R Squire
Jun 6, 2000·Learning & Memory·B Gerber, R Menzel
Sep 21, 2000·Behavioural Brain Research·E A AntoniadisR J McDonald
Mar 13, 2002·Nature Neuroscience·Satoshi KidaAlcino J Silva
Apr 5, 2002·Journal of Molecular Neuroscience : MN·Dirk MotzkusErik Maronde
May 15, 2002·Nature Neuroscience·Feng WeiMin Zhuo
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Zdenka Travnickova-BendovaPaolo Sassone-Corsi
Jun 6, 2002·Behavioural Brain Research·Dipesh Chaudhury, Christopher S Colwell
Jun 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Carolina AbarcaRainer Spanagel
Aug 29, 2002·Nature·Steven M Reppert, David R Weaver
Oct 9, 2002·Nature Neuroscience·Jaime AthosDaniel R Storm

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Citations

Sep 1, 2018·Endocrine Reviews·Pureum KimOliver Rawashdeh
Feb 6, 2020·Frontiers in Aging Neuroscience·Paula AdlerDaniel Figeys
Oct 31, 2020·BMC Biology·Snehajyoti ChatterjeeTed Abel
Jan 22, 2021·Neuroscience and Biobehavioral Reviews·Andrew B LehrScott H Deibel
Jun 10, 2021·Journal of Neurology·Carolin HoyerKristina Szabo

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Methods Mentioned

BETA
nuclear translocation
dissection
X-ray
immunoprecipitation

Software Mentioned

PhosphoSitePlus

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