PMID: 7546830Jan 1, 1995Paper

Clodronate and other bisphosphonates as supportive therapy in osteolysis due to malignancy

Acta Oncologica
I Elomaa, C Blomqvist

Abstract

Clodronate, one of the most investigated bisphosphonates, has been clinically utilised for over 10 years in malignancy. It is the most used, most effective and safest drug in the treatment of hypercalcaemia. It inhibits lytic bone destruction, prevents bone fractures and relieves bone pain. Supportive clodronate therapy may even reduce hypercalcaemia mortality and the morbidity caused by osteolysis. These results have stimulated studies on the patients' quality of life. New methods for the measurement of bone resorption, such as the degradation product of type I collagen (ICTP), may improve the possibility of monitoring the effect of clodronate. Comparative studies with different bisphosphonates in hypercalcaemia and long-term controlled trials using bisphosphonates as supportive therapy in osteolysis due to malignancy are reviewed.

References

Jan 1, 1992·International Urology and Nephrology·I ElomaaJ Seppänen
Jan 1, 1992·Journal of Pain and Symptom Management·D S ErnstE Bruera
Mar 12, 1992·International Journal of Cancer. Journal International Du Cancer·R RizzoliJ P Bonjour
Jul 5, 1992·The New England Journal of Medicine·R E CurtisR N Hoover
Aug 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A R BelchB Zee
Feb 2, 1991·BMJ : British Medical Journal·U Pedersen-Bjergaard, J Myhre
Jan 20, 1990·Lancet·J A KanisA H Paterson
Jan 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M Sato, W Grasser
Aug 1, 1987·European Heart Journal·N H Areskog
Jan 1, 1989·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·S Adami, M Mian
May 18, 1985·Lancet·I ElomaaG H Borgström
Apr 1, 1986·European Journal of Cancer & Clinical Oncology·J W ElteH P Sleeboom
May 1, 1987·Archives of Internal Medicine·R S WitteT P Jacobs
Aug 1, 1985·The Journal of Clinical Investigation·G R MundyS M D'Souza
May 10, 1986·British Medical Journal·J A KanisA J Yates
Jan 1, 1986·Clinical Endocrinology·I FogelmanJ A Bevan
May 1, 1985·British Journal of Cancer·R C PercivalJ A Kanis
Mar 1, 1988·Annals of Internal Medicine·W J BurtisA F Stewart
Jan 1, 1986·Acta Medica Scandinavica·C P Blomqvist
Jun 1, 1985·British Journal of Cancer·R L O'Grady, D A Cameron
Dec 1, 1985·British Journal of Urology·G H UrwinJ A Kanis
Feb 26, 1983·Lancet·H M BounameauxF Chatelanat
Jun 11, 1983·Lancet·J A KanisR G Russell
Jul 1, 1984·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P J CoxJ S Dawborne
Jan 1, 1982·Metabolic Bone Disease & Related Research·P D DelmasP J Meunier
Jun 23, 1983·The New England Journal of Medicine·A JungM E Kitler
Jun 28, 1984·The New England Journal of Medicine·G R MundyT J Martin
Apr 1, 1983·Urology·S C Jacobs
Feb 7, 1980·The New England Journal of Medicine·E S SirisR E Canfield
Jul 1, 1981·Clinical Pharmacology and Therapeutics·K A Conrad, S M Lee
Feb 1, 1982·The American Journal of Medicine·A Jung
Mar 1, 1982·Clinical Pharmacology and Therapeutics·G J YakatanJ J Benedict
Apr 1, 1982·The Journal of Clinical Endocrinology and Metabolism·P D DelmasP J Meunier

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Citations

Dec 9, 2003·The Breast : Official Journal of the European Society of Mastology·David Cameron
Oct 21, 2000·Acta Oncologica·I Elomaa
Jan 1, 1996·Acta Oncologica·O S Nielsen
Jan 1, 1996·Acta Oncologica·C Blomqvist, I Elomaa
Mar 28, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Guoyin LiuJianning Zhao

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