PMID: 8968035Dec 1, 1996Paper

Clodronate decreases the frequency of skeletal metastases in women with breast cancer

Bone
J A KanisS Ashley

Abstract

The aims of this study were to determine the effects of the bisphosphonate, clodronate, on the incidence of skeletal metastases and associated morbidity in women with advanced breast cancer. 133 women with recurrent breast cancer, but no evidence of skeletal metastases, were randomly allocated to receive clodronate 1600 mg daily by mouth or an identical placebo for 3 years under double-blind conditions at two clinical oncology centers in the UK and Canada. Main outcome measures included the occurrence of skeletal metastases, as judged by sequential bone scans and radiographs, and the morbidity associated with skeletal metastases comprising the incidence of hypercalcemia, vertebral, and nonvertebral fractures, and bone pain assessed by the requirements for skeletal radiotherapy. The number of patients developing skeletal metastases was lower in clodronate-treated patients than with placebo (15 vs. 19), but was not significantly different. The number of skeletal metastases was significantly lower with clodronate treatment than with placebo (32 vs. 63; p < 0.005). The complications of skeletal disease were fewer by 26% in clodronate-treated patients compared to controls (p < 0.01). Compared to placebo, significant effects in favor...Continue Reading

References

Jan 1, 1992·Journal of Pain and Symptom Management·D S ErnstE Bruera
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N J BundredJ G Ratcliffe
Mar 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D ThiebaudP Burckhardt
Mar 9, 1985·British Medical Journal·J A Kanis, A J Yates
Mar 1, 1985·Archives of Internal Medicine·E RyzenR Hicks
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T TaubeJ A Kanis
May 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E V McCloskeyJ A Kanis

❮ Previous
Next ❯

Citations

Nov 22, 2001·Pharmazie in unserer Zeit·P SchmidK Possinger
Jan 1, 1993·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·J J Body
Jan 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisM N Beneton
Jan 15, 2003·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Mitsuru KoizumiEtsuro Ogata
May 9, 2008·Calcified Tissue International·Peter VestergaardLeif Mosekilde
Oct 5, 2010·International Orthopaedics·Arne StreitbuergerJendrik Hardes
Feb 2, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jean-Jacques Body
Sep 27, 2005·Breast Cancer Research and Treatment·Luz-Milva Rodríguez-RodríguezNorberto Batista
Oct 12, 2001·Current Oncology Reports·J R Gralow
May 27, 2004·Current Oncology Reports·Dawn Hershman, Rashmi Narayanan
Dec 17, 2008·Current Oncology Reports·Dawn L HershmanKatherine D Crew
Dec 10, 2002·Cancer Treatment Reviews·H L Neville-WebbeR E Coleman
Jul 1, 1996·Cancer Treatment Reviews·J J BodyM Piccart
Jul 29, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·D Inoue, T Matsumoto
Sep 12, 2003·Journal of Pain and Symptom Management·Célia Roemer-BécuwePaul Walker
Jul 21, 1998·Endocrinology and Metabolism Clinics of North America·N B Watts
Nov 3, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R E ColemanJ Ford
Oct 26, 1999·Critical Reviews in Oncology/hematology·T A Plunkett, R D Rubens
May 14, 1999·Trends in Endocrinology and Metabolism : TEM·A H Paterson
Feb 23, 2002·Joint, Bone, Spine : Revue Du Rhumatisme·Philippe Orcel, Johann Beaudreuil
Nov 19, 2003·Breast Cancer Research and Treatment·Melinda MerrellKatri S Selander
Aug 14, 1999·Journal of Internal Medicine·B KristensenH T Mouridsen
Aug 6, 1998·The New England Journal of Medicine·I J DielG Bastert
Jul 31, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·I J DielF Schuetz
Apr 5, 2001·Journal of the National Cancer Institute·R J Cook, P Major
Feb 4, 2003·American Journal of Clinical Oncology·Jonathan R Green, Philippe Clézardin
Feb 4, 2003·American Journal of Clinical Oncology·Robert E Coleman
Nov 1, 2002·Current Opinion in Oncology·Jonathan R Green
Jan 19, 2005·Anti-cancer Drugs·Frieder Bauss, Jean-Jacques Body
Aug 14, 1998·BMJ : British Medical Journal·E Barrett-Connor
Mar 12, 1999·Annual Review of Medicine·J R Berenson, A Lipton
Jul 25, 2009·Stroke; a Journal of Cerebral Circulation·Afshin A DivaniAndreas R Luft
Jul 7, 1999·Journal of Clinical Pharmacology·D L Brown, R Robbins
Apr 28, 2005·Clinical Journal of Oncology Nursing·Karen K SwensonLynne M Schroeder
Feb 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P J BekkerC R Dunstan
Jul 2, 2003·Drugs & Aging·Nicola Lucio LiberatoGiovanni Barosi
May 13, 2009·Clinical Drug Investigation·Bruno FredianiGiovanni Cremonesi

❮ Previous
Next ❯

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