Clofibrate as an Adjunct to Phototherapy for Unconjugated Hyperbilirubinemia in Term Neonates

Indian Journal of Pediatrics
Prasad KumarB Vishnu Bhat

Abstract

To evaluate the efficacy of oral clofibrate as an adjunct to phototherapy for unconjugated hyperbilirubinemia in term neonates. This randomized controlled trial was done in the level III neonatal intensive care unit (NICU) of a tertiary care hospital. Ninety term neonates with unconjugated hyperbilirubinemia with serum bilirubin 15-25 mg/dl were randomized to either intervention group (single dose of clofibrate in a dose of 50 mg/kg prior to starting phototherapy) or standard care group (only phototherapy). Primary outcome was absolute fall in bilirubin by 48 h. Secondary outcomes were duration of phototherapy, absolute fall in bilirubin levels at 12, 24, 36, 48 h, need for exchange transfusion and incidence of side-effects. After 48 h of intervention, significantly lower bilirubin levels were noted in the intervention group compared to standard care group with a mean difference of 7 mg/dl (95% CI 6.7 mg/dl to 7.2 mg/dl). Duration of phototherapy required was less in the intervention group compared to standard care group with mean difference of 23.82 h (95% CI 30.46 h to 17.18 h). Exchange transfusion was needed for 4 neonates in the standard care group and none in the intervention group. No side-effects were noted with clofibr...Continue Reading

References

Aug 1, 1995·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·P BourgetJ C Gabilan
Dec 16, 1998·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·J C Gabilan
Jul 3, 2004·Pediatrics·UNKNOWN American Academy of Pediatrics Subcommittee on Hyperbilirubinemia
Oct 18, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Marco Fidaleo
Jul 9, 2009·Indian Journal of Medical Sciences·Sedigheh Hossein Pour SakhaMohammad Ebrahim Rahbani
Apr 2, 2011·European Journal of Pediatrics·Tao XiongDezhi Mu
Oct 10, 2012·The Journal of Pediatrics·Vinod K BhutaniUNKNOWN Initial Clinical Testing Evaluation and Risk Assessment for Universal Screening for Hyperbilirubinemia Study Group
Oct 2, 2013·Iranian Red Crescent Medical Journal·Zohre TorabiAkefeh Ahmadiafshar

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Citations

Dec 14, 2012·The Cochrane Database of Systematic Reviews·Maryam GholitabarRosalind Lai
Aug 6, 2017·Indian Journal of Pediatrics·Deepak Chawla

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