Clomiphene citrate and human chorionic gonadotropin are both effective in restoring testosterone in hypogonadism: a short-course randomized study

BJU International
Mohamad HabousGordon Muir

Abstract

To compare serum testosterone response and symptom improvement in men with hypogonadism in response to treatment with clomiphene citrate (CC), human chorionic gonadotropin (hCG), or a combination of both therapies. A total of 282 men with hypogonadism, wishing to preserve their fertility, were randomized to one of three treatment arms: CC 50 mg (n = 95); 5000 IU hCG injections twice weekly (n = 94); or a combination of both therapies (CC + hCG; n = 94). All participants had complete medical history and had undergone thorough physical examination, including body mass index (BMI) assessment. Laboratory tests included serum total testosterone and glycated haemoglobin (HbA1c) measurements. Quantitative Androgen Deficiency in the Aging Male (qADAM) questionnaire scores were also recorded. Morning samples of total serum testosterone levels were assessed at three time points: baseline, 1 and 3 months. Testosterone levels increased at 1 and 3 months in all three groups. The mean baseline testosterone level was 2.31 ± 0.66 nmol/L, BMI was 30.8 ± 6.2 kg/m2 , and qADAM score was 20.5 ± 3.8. Testosterone levels increased in all groups at all time points, with a final mean value of 5.17 ± 1.77 nmol/L (223% increase) with no statistically si...Continue Reading

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Citations

Feb 13, 2019·The Journal of Clinical Endocrinology and Metabolism·Bradley D Anawalt
Aug 14, 2019·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Vinayak MadhusoodananRanjith Ramasamy
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Apr 23, 2021·Andrologia·José de Oliveira Vilar NetoElizabeth De Francesco Daher
May 3, 2021·Sexual Medicine Reviews·Omer A RaheemThomas J Walsh
Jan 9, 2022·International Journal of Impotence Research·Maria Camila Suarez ADaniel E Nassau

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