Clomiphene citrate as a possible cause of a psychotic reaction during infertility treatment

Human Reproduction
F SiedentopfH Kentenich

Abstract

Secondary side-effects often occur in women undergoing hormonal stimulation treatment with clomiphene citrate. In general 10.4% of women experience hot flushing, 5.5% have complaints caused by enlargement of the ovaries and 3.5% experience central nervous symptoms (nervousness, sleeplessness, headaches, visual disturbances, vertigo). During ovarian stimulation with clomiphene citrate for in-vitro fertilization, a 32 year old patient developed psychotic symptoms, commencing 3 days after initiation of treatment. Hospitalization in the psychiatric ward became necessary when severe formal and rational thought disturbances arose together with perceptory and sensory delusions. Under neuroleptic treatment the symptoms improved. Nevertheless, follow-up psychiatric care on an outpatient basis was deemed necessary. The infertility treatment was continued with human menopausal gonadotrophin stimulation. Psychiatric instability occurred neither at this point nor during the 2 year follow-up observation period. Both an exogenous psychosis (ICD F23.9) as well as the exacerbation of an endogenous psychosis (ICD F29) may be considered for the differential diagnosis. The stimulation with clomiphene citrate in connection with the physical and psy...Continue Reading

Citations

Jan 19, 2011·Human Reproduction·Katherine E WilliamsNatalie L Rasgon
Nov 28, 2001·Acta Psychiatrica Scandinavica·V Mahé, A Dumaine
Aug 21, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mary V Seeman
Oct 17, 2007·The Psychiatric Clinics of North America·Linda Hammer Burns
Jun 10, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Oliver Grimm, Petra Hubrich
Jan 9, 2007·Psychosomatics·Aashish R Parikh, Barry I Liskow
Dec 13, 2006·Fertility and Sterility·Cyrus GhobadiWilliam L Ledger
Jul 6, 2014·General Hospital Psychiatry·José Daniel Machado RodriguesIan Fraser Brockington
Sep 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·John J BorgRoland Z Kozlowski
Jul 30, 2005·Journal of Psychosomatic Obstetrics and Gynaecology·So-Hyun ChoiDonna Stewart

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