Clomiphene citrate for treatment of acromegaly not controlled by conventional therapies

The Journal of Clinical Endocrinology and Metabolism
Felipe H DuarteMarcello D Bronstein

Abstract

Oral estrogens, alone or in combination with somatostatin receptor ligands, have been shown to control acromegaly in women. Selective estrogen receptor modulators resulted in similar effects in both genders. Clomiphene citrate (CC), a selective estrogen receptor modulator that increases LH and FSH secretion, improves hypogonadism and fertility outcomes. To assess the impact of CC on serum IGF-1 and T levels in male acromegalic patients not controlled by surgery, radiotherapy, and/or medical treatment. In this prospective, open-label, single-center trial, CC (50 mg/d) was added to previous medical treatment for 3 months. Hormonal assessment was performed before and during the intervention. Sixteen male patients (median age, 52.8 y; range, 36-79 y) met the following criteria: IGF-1 above the upper limit of normal range for at least 1 year despite the use of available medical therapies, and T levels within or below the third inferior tertile of normality. Serum IGF-1 levels decreased by 41% (mean ± SD, 424 ± 108 to 250 ± 83 ng/mL; P < .0004), leading 44% (seven of 16) of the patients to achieve normal IGF-1 levels. Total serum T levels increased by 209% (282 ± 201 to 497 ± 310 ng/dL), reaching normal levels in 67% (four of six) of...Continue Reading

Citations

Jan 15, 2016·Expert Opinion on Investigational Drugs·S Störmann, J Schopohl
Oct 28, 2016·Endocrine·Felipe H DuarteMarcello D Bronstein
Nov 17, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Yair Liel
Feb 27, 2016·F1000Research·Georgia Ntali, Niki Karavitaki
Jan 28, 2020·Reviews in Endocrine & Metabolic Disorders·Júlia Vieira Oberger Marques, Cesar Luiz Boguszewski
Oct 14, 2019·The Journal of Clinical Endocrinology and Metabolism·Andrea GiustinaShlomo Melmed
Jul 27, 2018·Case Reports in Endocrinology·Juan D PalaciosAtil Y Kargi
Jul 28, 2018·Nature Reviews. Endocrinology·Shlomo MelmedAndrea Giustina
Jun 28, 2019·European Endocrinology·Elena V VarlamovMaria Fleseriu
Nov 1, 2015·Expert Review of Endocrinology & Metabolism·Ferdinand Roelfsema, Gerrit van den Berg
Oct 21, 2020·Pituitary·Maria FleseriuShlomo Melmed
Mar 31, 2021·Expert Opinion on Pharmacotherapy·Ximene AntunesMônica R Gadelha
Apr 30, 2021·Journal of Medical Case Reports·Sasan MirfakhraeeJessica Abramowitz
Apr 28, 2021·Archives of Endocrinology and Metabolism·Heraldo Mendes GarmesMarcello Delano Bronstein
Jun 15, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Safa KhaldiKoussay Ach
Aug 21, 2021·BMC Endocrine Disorders·Shimpei IwataMasatoshi Nomura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.