Clomipramine challenge responses covary with Tridimensional Personality Questionnaire scores in healthy subjects

Biological Psychiatry
R G RueggR N Golden

Abstract

Cloninger's Unified Biosocial Theory of Personality postulates a relationship between the relative functional activity of central serotonergic, dopaminergic, and noradrenergic neurotransmitter systems, and the strength of three elemental dimensions of personality. These dimensions are Harm Avoidance, Novelty Seeking, and Reward Dependence, respectively. Accordingly, we predicted that neuroendocrine responses to serotonergic challenge would correlate with Harm Avoidance scores, but not with Novelty Seeking or Reward Dependence scores. We examined the relationship between the prolactin and cortisol responses to a 12.5-mg intravenous clomipramine challenge and these personality dimensions as measured by Cloninger's Tridimensional Personality Questionnaire in 32 healthy subjects. The cortisol response correlated only with Harm Avoidance scores, as predicted; however, prolactin response did not correlate with Harm Avoidance scores. Instead, it demonstrated an inverse relationship with Novelty Seeking scores. There was a positive relationship of baseline prolactin with Harm Avoidance in a post hoc analysis. Cortisol response to serotonergic challenge may be a better indicator for responsivity of serotonergic systems as they relate to...Continue Reading

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Citations

Oct 25, 2001·Hormones and Behavior·J C RosenblittD M Quadagno
Jan 22, 2000·Psychiatry Research·A R PeirsonC R Cloninger
May 20, 2000·Psychoneuroendocrinology·G GerraF Brambilla
Jan 9, 2001·Journal of Substance Abuse·G GerraF Brambilla
Sep 5, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A J Bond
Feb 20, 2010·Neuropsychiatric Disease and Treatment·Donatella MarazzitiAntonio Ciapparelli
May 26, 2012·Journal of Psychiatric Research·Jaime ChamorroCarlos Blanco
Aug 23, 2011·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Sara ShabaniOmid Rezaei
Mar 13, 2016·Neuroscience and Biobehavioral Reviews·Irina Trofimova, Trevor W Robbins
Sep 23, 2008·Psychophysiology·Diane L Santesso, Sidney J Segalowitz
Jan 9, 2004·CNS Spectrums·Vivian MitropoulouLarry J Siever

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