PMID: 11902426Mar 21, 2002Paper

Clomipramine suppresses postnatal REM sleep without increasing wakefulness: implications for the production of depressive behaviors

Sleep
P Feng, Yuxian Ma

Abstract

Clomipramine (CLI), a REM sleep suppressant, alleviates symptoms of depression in adults but produces depressive behaviors if applied neonatally. Both effects of CLI as applied to adults and to neonates have been interpreted as consequences of its involvement in REM sleep deprivation. However, the paradox of these conflicting effects remains to be understood. The current study attempts to find the possible answer by studying the effects of CLI on postnatal sleep. Eight postnatal rats were evaluated polysomnographically for nine days. Four rats were treated with CLI, 40 mg/kg/day for six days, and four rats were treated with equivolume saline during the same period. The results showed that 1) CLI treatment did not reduce the time of phasic muscle activity which appears during slow wave EEG as it did during REM sleep; 2) during treatment, rats treated with CLI had 44.66%-68.62% REM sleep reduction, varied according to age; 3) REM sleep reduction during treatment was generally compensated by non-REM sleep, so that total sleep (and wakefulness) was comparable to that experienced by rats treated with saline; 4) an obvious REM sleep rebound was observed after drug withdrawal at the age of P19. These results suggest that 1) the stage ...Continue Reading

Citations

Apr 14, 2010·The European Journal of Neuroscience·Markus LagusTiina Paunio
Jun 20, 2008·Journal of Psychopharmacology·P FengK P Strohl
Jul 1, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·B S AswathyKamalesh K Gulia

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