PMID: 6159865Nov 1, 1980Paper

Clomipramine treatment of obsessive-compulsive disorder. II. Biochemical aspects

Archives of General Psychiatry
P ThorénL Träskman

Abstract

Concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), the dopamine metabolite homovanillic acid, and the noradrenaline metabolite 4-hydroxy-3-methoxyphenyl glycol were measured in CSF before and after three weeks' treatment of severe obsessive-compulsive disorder with clomipramine hydrochloride. Patients who responded to clomipramine treatment had significantly higher CSF levels of 5-HIAA before treatment. The amelioration of obsessive-compulsive symptoms was positively correlated to the reduction of CSF concentrations of 5-HIAA during clomipramine treatment but negatively correlated to plasma concentrations of clomipramine. Reduction of CSF concentrations of 5-HIAA, which probably reflects drug action on central serotonin neurons, was maximal at a plasma clomipramine concentration of about 300 nmole/L. At higher levels, the reduction of CSF levels of 5-HIAA was smaller. The antiobsessive effect of clomipramine may be connected to its capacity to inhibit serotonin uptake.

Citations

Nov 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·J VallejoJ M Menchón
Jan 1, 1990·Acta Psychiatrica Scandinavica·E ErikssonK Modigh
May 1, 1986·Journal of Child Psychology and Psychiatry, and Allied Disciplines·J L Rapoport
Jan 1, 1986·Annals of the New York Academy of Sciences·L Träskman-BendzD Schalling
Mar 1, 1984·Acta Psychiatrica Scandinavica·M AsbergL Träskman-Bendz
Jan 1, 1994·The Journal of the American Academy of Psychoanalysis·M Zuelzer, J W Maas
Aug 1, 1997·The British Journal of Psychiatry : the Journal of Mental Science·M LindsayG Andrews
Aug 2, 2001·Clinical Neuropharmacology·J Micallef, O Blin
Nov 20, 2001·International Clinical Psychopharmacology·D J SteinP Tanghoj
Nov 1, 1988·The British Journal of Psychiatry : the Journal of Mental Science·I Marks, G O'Sullivan
Aug 1, 1990·American Journal of Medical Genetics·D E Comings
Jul 1, 1991·Acta Psychiatrica Scandinavica·B VitielloE Friedman
Jun 9, 1998·Annals of the New York Academy of Sciences·M Asberg
Jun 1, 1995·Journal of Speech and Hearing Research·S V StagerJ L Rapoport
Dec 22, 2004·The Journal of Comparative Neurology·Pokman ChanStuart C Sealfon
Jun 11, 2016·Expert Review of Neurotherapeutics·Nandita HazariShyam Sundar Arumugham
Jul 1, 1990·DICP : the Annals of Pharmacotherapy·M W Kelly, C W Myers
Jun 1, 1997·The British Journal of Psychiatry : the Journal of Mental Science·P MonteleoneM Maj
Nov 1, 1987·Drug Intelligence & Clinical Pharmacy·H HermeshH Munitz
Aug 29, 1991·The New England Journal of Medicine·W Z PotterH Manji
Jan 1, 1993·Psychopharmacology·J K HsiaoD Pickar
Jan 10, 2002·Zeitschrift für Psychosomatische Medizin und Psychotherapie·H J Grabe, H J Freyberger
Feb 18, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·R Gross-IsseroffA Weizman
Jul 2, 2005·Journal of Psychiatric Practice·B A Fallon, S J Mathew
Mar 1, 1998·Human Nature : an Interdisciplinary Biosocial Perspective·H E Fisher
Feb 10, 2004·CNS Spectrums·John H GreistUNKNOWN World Council of Anxiety
May 7, 2011·Luminescence : the Journal of Biological and Chemical Luminescence·Zhongling JiJianguo Li
Sep 1, 1991·DICP : the Annals of Pharmacotherapy·S K Guthrie
Jul 1, 1988·Acta Psychiatrica Scandinavica·H HermeshH Munitz
Jan 1, 1990·Annals of the New York Academy of Sciences·T R InselD L Murphy
Jul 13, 2006·Expert Review of Neurotherapeutics·Kunitoshi Kamijima, Mayumi Aoki
Mar 17, 2007·The International Journal of Clinical and Experimental Hypnosis·Claire Frederick
Apr 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kaushik ChakrabartySumant Khanna
Jan 21, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jesse WoodSusanne E Ahmari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.