PMID: 6968910Sep 1, 1980Paper

Clonal analysis of proliferation and differentiation of paired daughter cells: action of granulocyte-macrophage colony-stimulating factor on granulocyte-macrophage precursors

Proceedings of the National Academy of Sciences of the United States of America
D Metcalf

Abstract

Mouse granulocyte-macrophage progenitor cells were stimulated to divide by the granulocyte-macrophage colony-stimulating factor (GM-CSF). The two daughter cells were separated; one daughter was transferred to medium containing a high concentration of GM-CSF, the other to medium containing a low concentration. Daughter cell-derived clones in the presence of 2500 units of GM-CSF had average cell cycle times 3.5 +/- 2.5 (SEM) hr shorter than clones derived from the paired daughter cell stimulated by 50 units of GM-CSF. Final colony size achieved after stimulation by 50 units of GM-CSF was always smaller than that of colonies stimulated by 2500 units of GM-CSF. In 8 of 41 instances, colonies stimulated by 50 units of GM-CSF developed, or were composed only of, macrophage populations in contrast to the granulocytic composition of colonies derived from the paired daughter cell growing in the presence of 2500 units of GM-CSF. The regulator GM-CSF appears able to directly influence cell cycle times and the pathway of differentiation entered by many bipotential granulocyte-macrophage precursor cells.

Citations

Jan 1, 1989·Immunologic Research·R G Coffey
Feb 1, 1987·Developmental Biology·C C WylieJ C Smith
Jan 1, 1988·The International Journal of Biochemistry·L C OlsenI F Pryme
Apr 6, 2004·Developmental and Comparative Immunology·Daniel R BarredaMiodrag Belosevic
Feb 5, 2002·Annual Review of Physiology·Bruce C Trapnell, Jeffrey A Whitsett
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·J AudetC J Eaves
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·A Kelso, P Groves
Feb 17, 2010·Cellular and Molecular Life Sciences : CMLS·Gabriela BrumattiPaul G Ekert
Jan 1, 1990·Cellular Signalling·A D Whetton
Jan 1, 1993·Cancer Investigation·A Lindemann, R Mertelsmann
Jun 1, 1997·Baillière's Clinical Haematology·C J Eaves, A C Eaves
Jan 1, 1985·Critical Reviews in Oncology/hematology·R Taetle, J A Koziol
Sep 1, 1991·The American Journal of Medicine·R KurzrockJ U Gutterman
Jan 1, 1984·Leukemia Research·E Frindel, C Vendrely
Jan 1, 1985·Leukemia Research·R E GallagherE C Muly
May 1, 1982·Differentiation; Research in Biological Diversity·G T Matioli
Mar 25, 2015·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Palash BhattacharyaBellur S Prabhakar
Apr 19, 2015·Stem Cell Research & Therapy·Haydn C-Y Liang, Juan Carlos Zúñiga-Pflücker
Aug 11, 2011·PloS One·Hanif Javanmard KhamenehChristiane Ruedl
Dec 1, 1994·The Annals of Pharmacotherapy·D K Farver, L A Hansen
Mar 1, 1984·Immunology Today·N A Nicola, M Vadas
Jun 11, 2017·FEBS Letters·Ilaria LungerMichael A Rieger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.