PMID: 6976392Jan 1, 1982Paper

Clonal characteristics of cutaneous T cell lymphomas: cytogenetic evidence from blood, lymph nodes, and skin

The Journal of Investigative Dermatology
P C NowellE C Vonderheid

Abstract

Chromosome studies were done on mitogen-stimulated lymphocytes from one or more tissues (blood, lymph nodes, skin lesions) in 15 patients with mycosis fungoides or Sézary syndrome. A cytogenetically abnormal clone was found in 10 individuals, including 6 with data from several tissues. In 4 cases the same aberrant clone was identified in a skin lesion as well as in blood and/or lymph node. The abnormal chromosome patterns ranged from hypodiploid to hypertetraploid, and there was no evidence of unrelated karyotypically-altered lines at different sites. A 6q- chromosome, previously reported in acute lymphocytic leukemia, was found in 2 patients. The results support the concept that cutaneous T cell lymphomas (CTCL) are clonal disorders, presumably unifocal in origin, with the skin lesions populated by cells from the same neoplastic clone that involves lymph nodes and blood.

Citations

Oct 1, 1984·International Journal of Dermatology·N C McFadden
Jan 31, 2003·Genes, Chromosomes & Cancer·Xin MaoSean Whittaker
Nov 5, 2003·The Journal of Pathology·Martina ProchazkovaJean-Philippe Merlio
May 1, 1989·The British Journal of Dermatology·E RalfkiaerG L Wantzin
Jan 1, 1985·Critical Reviews in Clinical Laboratory Sciences·A A Sandberg
Jan 1, 1985·Archives of Dermatological Research·J ToonstraH Baart de la Faille
Apr 23, 2004·American Journal of Medical Genetics. Part a·Beau BattonSamir Jamil
Feb 5, 1987·The New England Journal of Medicine·R EdelsonG Plewig
Apr 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·M ComolaN Canal
Aug 29, 1985·The New England Journal of Medicine·V BertnessP A Bunn
Sep 1, 1990·The Journal of Pathology·D Slater
Jan 1, 1983·Cancer Metastasis Reviews·S R Wolman
Jun 23, 2007·Genes, Chromosomes & Cancer·Martina ProchazkovaJean-Philippe Merlio
Jan 1, 1988·Medical Oncology and Tumor Pharmacotherapy·G Chenevix-TrenchF G Behm

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