PMID: 8967786Apr 1, 1996Paper

Clonal disease in extracutaneous compartments in cutaneous T-cell lymphomas. A comparative study between cutaneous T-cell lymphomas and pseudo lymphomas

Archives of Dermatological Research
S N DommannG Burg

Abstract

Extracutaneous involvement is a sign of poor prognosis in cutaneous T-cell lymphomas (CTCL). Unfortunately it becomes clinically and histologically manifest only late in the course of the disease. It was the purpose of this study to detect clonality in peripheral blood, lymph nodes and bone marrow samples at times when extracutaneous involvement cannot otherwise be demonstrated. In addition to skin biopsies, peripheral blood, lymph node and bone marrow samples from a total of 25 patients were analysed by Southern blotting for clonal gene rearrangement of the T-cell receptor beta-chain. Six of the patients were suffering from mycosis fungoides (MF), four from non-MF CTCL (pleomorphic T-cell lymphomas), seven from Sézary syndrome (SS), eight from pseudolymphoma (insect bites) (PSL), and one from lymphomatoid papulosis (LP). Clonal TcR b gene rearrangements were found in patients with MF in four of five skin probes as well as in two of two lymph node samples and in one of two peripheral blood samples. In SS patients, all skin probes (seven of seven), lymph node samples (six of six), peripheral blood samples (six of six) and one bone marrow specimen had a clonal TcR beta gene rearrangement. In patients with non-MF CTCL, two of four...Continue Reading

References

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Citations

Oct 3, 2006·The American Journal of Dermatopathology·Dmitry V KazakovWerner Kempf
Aug 20, 2003·The Journal of Investigative Dermatology·Olivier DereureJean-François Eliaou
Jun 8, 2001·American Journal of Clinical Pathology·D JonesY O Huh
Nov 29, 2005·Journal of the American Academy of Dermatology·Nicola PimpinelliUNKNOWN International Society for Cutaneous Lymphoma
Jul 5, 2003·Blood·Robert GniadeckiHans Christian Wulf
Jun 1, 2001·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·K DadejI Gòrska-Flipot

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