Clonal evolution and heterogeneity in metastatic head and neck cancer-An analysis of the Austrian Study Group of Medical Tumour Therapy study group

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Thomas MelchardtAlexander Egle

Abstract

Tumour heterogeneity and clonal evolution within a cancer patient are deemed responsible for relapse in malignancies and present challenges to the principles of targeted therapy, for which treatment modality is often decided based on the molecular pathology of the primary tumour. Nevertheless, the clonal architecture in distant relapse of head and neck cancer is fairly unknown. For this project, we analysed a cohort of 386 patients within the Austrian Registry of head and neck cancer. We identified 26 patients with material from the primary tumour, the distant metastasis after curative first-line treatment and a germline sample for analysis of clonal evolution. After pathological analyses, these samples were analysed using a targeted massively parallel sequencing (MPS) panel of 257 genes known to be recurrently mutated in head and neck cancer plus a genome-wide SNP-set. Despite histological diagnosis of distant metastasis, no corresponding mutation in the supposed metastases was found in two of 23 (8.6%) evaluable patients suggesting a primary tumour of the lung instead of a distant metastasis of head and neck cancer. We observed a branched pattern of evolution in 31.6% of the analysed patients. This pattern was associated with...Continue Reading

Citations

Oct 11, 2019·Precision Clinical Medicine·Demeng Chen, Cun-Yu Wang
Apr 10, 2019·International Journal of Cancer. Journal International Du Cancer·Tilmann BochtlerAlbrecht Stenzinger
Nov 2, 2019·Cancer Cell International·Maria PalmieriElisa Frullanti
Dec 22, 2019·Cells·Óscar Rapado-GonzálezMaría Mercedes Suárez-Cunqueiro
May 30, 2020·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·Paolo PisaniAngelo Zigliani
Mar 7, 2021·Critical Reviews in Oncology/hematology·Adriana Castelo de MouraEliete Neves Silva Guerra
Apr 10, 2021·International Journal of Clinical Oncology·Isamu Hoshino
Jun 3, 2021·International Journal of Molecular Sciences·Teresa MagnesThomas Melchardt

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