Clonal evolution as pathogenetic mechanism in relapse of primary CNS lymphoma

Neurology
Hendrik PelsM Deckert

Abstract

Comparative investigation of immunoglobulin (Ig) heavy chain gene rearrangements and DNA sequence analyses of a primary lymphoma of the CNS (PCNSL) and its recurrence revealed that both tumors used the same Ig gene segment. In addition to shared somatic mutations, the primary and the recurrent PCNSLs harbored somatic mutations unique to each tumor. Clonal evolution rather than subclone selection appears to underlie the development of tumor recurrence in this case.

Citations

Mar 5, 2011·Neuro-oncology·Lakshmi NayakLisa M DeAngelis
Sep 20, 2008·Blood·Manuel Montesinos-RongenMartina Deckert
Nov 11, 2005·Current Opinion in Neurology·Scott R Plotkin
Nov 23, 2006·Hematology/oncology Clinics of North America·Fabio M Iwamoto, Lisa M DeAngelis
Jun 21, 2011·European Journal of Radiology·Gernot Schulte-AltedorneburgHendrik Pels
Nov 25, 2006·Hematology·Lisa M Deangelis, Fabio M Iwamoto
Jan 28, 2005·Journal of Neuro-oncology·Joachim M Baehring
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eric T Wong
May 18, 2021·Frontiers in Oncology·Kaiyan TaoXin Tian

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