Clonal evolution of chronic lymphocytic leukemia to acute lymphoblastic leukemia

Cancer Genetics and Cytogenetics
A N MohamedA Al-Katib

Abstract

A 38-year-old white man was diagnosed with B-cell chronic lymphocytic/prolymphocytic leukemia (CLL/PLL). The disease was unresponsive to a variety of chemotherapeutic regimes. One year after diagnosis, L3 blasts appeared in peripheral blood associated with more aggressive course. There was no change in the B-cell phenotype at that time, but cytogenetic analysis revealed the appearance of t(8;22)(q24;q11) and -21 superimposed on the original karyotype: 46,XY,+3,der(3)t(3;17)(p11;q12), t(11;14)(q13;q32),-17. These results indicate that the lymphoblastic transformation in our case emerged from the pre-existing B-lymphocytic clone.

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Citations

Aug 5, 1998·Cancer Genetics and Cytogenetics·S SavaşanE Abella
Nov 28, 2001·British Journal of Haematology·U N VaishampayanM Palutke
Jul 18, 2015·American Journal of Clinical Pathology·Zaher ChakhachiroYang O Huh
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May 22, 2004·Physiologia Plantarum·Luke HendricksonWah Soon Chow

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