PMID: 8603409Apr 1, 1996Paper

Clonal evolution of lung tumors

Cancer Research
G T ChungPamela H Rabbitts

Abstract

Lung tumors, particularly squamous cell carcinomas, are believed to develop through a series of morphological abnormalities, driven by underlying somatic genetic changes. One way of studying this process is to analyze candidate somatic genetic changes in samples of squamous metaplasia and bronchial dysplasia of varying degrees of severity as well as tumor from the same patient. This assumes a clonal relationship between these lesions. In this article, we provide evidence that adjacent, physically distinct bronchial abnormalities are clonally related. This has been achieved using a plaque assay technique to detect the same p53 mutation, present throughout a tumor specimen, in a small proportion of cells in an adjacent squamous metaplasia. In addition, we have obtained two dysplasia samples from a tumor-free patient over a 9-month interval. The earlier sample had one p53 mutation, whereas the later sample has to p53 mutations on different alleles. Thus, the pattern of clonal evolution detected in the parallel samples mimics the pattern seen in longitudinal samples and supports the analysis of synchronously collected samples for the study of tumor progression.

Citations

Sep 12, 2000·The American Journal of Pathology·Y YatabeT Takahashi
Nov 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·S P HussainC C Harris
Dec 9, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M C WuP Rabbitts
Oct 23, 1997·The Journal of Clinical Investigation·W A FranklinY E Miller
Dec 20, 2011·Gastroenterology·Susan GalandiukTrevor A Graham

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