PMID: 25730902Mar 3, 2015Paper

Clonal expansion and linear genome evolution through breast cancer progression from pre-invasive stages to asynchronous metastasis

Oncotarget
Anne Bruun KrøigårdMads Thomassen

Abstract

Evolution of the breast cancer genome from pre-invasive stages to asynchronous metastasis is complex and mostly unexplored, but highly demanded as it may provide novel markers for and mechanistic insights in cancer progression. The increasing use of personalized therapy of breast cancer necessitates knowledge of the degree of genomic concordance between different steps of malignant progression as primary tumors often are used as surrogates of systemic disease. Based on exome sequencing we performed copy number profiling and point mutation detection on successive steps of breast cancer progression from one breast cancer patient, including two different regions of Ductal Carcinoma In Situ (DCIS), primary tumor and an asynchronous metastasis. We identify a remarkable landscape of somatic mutations, retained throughout breast cancer progression and with new mutational events emerging at each step. Our data, contrary to the proposed model of early dissemination of metastatic cells and parallel progression of primary tumors and metastases, provide evidence of linear progression of breast cancer with relatively late dissemination from the primary tumor. The genomic discordance between the different stages of tumor evolution in this pa...Continue Reading

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Citations

Dec 17, 2015·Breast Cancer Research and Treatment·Diana H LiangAngel A Rodriguez
Apr 19, 2016·The Breast Journal·Anne Bruun KrøigårdTorben A Kruse
Feb 27, 2018·The Journal of Clinical Investigation·Marni B SiegelCharles M Perou
Feb 13, 2018·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Mohammed A AleskandaranyEmad A Rakha
Jul 20, 2020·BMC Cancer·Laura Rey-VargasSilvia J Serrano-Gomez
Nov 20, 2016·The Journal of Pathology·Anna K CasasentNicholas E Navin
Mar 10, 2017·Scientific Reports·Anne Bruun KrøigårdTorben A Kruse
Dec 12, 2018·Breast Cancer Research and Treatment·Kristin E RojasPatrick I Borgen
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Jan 20, 2018·BMC Cancer·Karen GomezSudhir Kumar
Aug 20, 2019·Breast Cancer Research and Treatment·Chieh-Yu LinRobert B West
Apr 5, 2018·Cancer Research·Willemijne A M E SchrijverCathy B Moelans
Oct 3, 2018·The American Journal of Pathology·Bethany N Hannafon, Wei-Qun Ding
Apr 26, 2021·The American Journal of Pathology·Samrita Dogra, Bethany N Hannafon

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