Clonal Expansion of Macrolide-Resistant Sequence Type 3 Mycoplasma pneumoniae, South Korea

Emerging Infectious Diseases
Joon Kee LeeEun Hwa Choi

Abstract

To investigate the genetic background for the emergence of macrolide resistance, we characterized the genetic features of Mycoplasma pneumoniae using multilocus sequence typing. Of the 146 M. pneumoniae strains collected during the 5 consecutive outbreaks of M. pneumoniae pneumonia during 2000-2016 in South Korea, macrolide resistance increased from 0% in the first outbreak to 84.4% in the fifth. Among the 8 sequence types (STs) identified, ST3 (74.7%) was the most prevalent, followed by ST14 (15.1%). Macrolide-susceptible strains comprised 8 different STs, and all macrolide-resistant strains were ST3 (98.3%) except 1 with ST14. The proportion of macrolide-resistant strains in ST3 remained 2.2% (1/46) until the 2006-2007 outbreak and then markedly increased to 82.6% (19/23) during the 2010-2012 outbreak and 95.0% (38/40) during the 2014-2016 outbreak. The findings demonstrated that clonal expansion of ST3 M. pneumoniae was associated with the increase in macrolide resistance in South Korea.

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Citations

Jun 23, 2020·Emerging Infectious Diseases·Yu-Chin ChenTu-Hsuan Chang
Aug 21, 2020·Emerging Infectious Diseases·Miyuki MorozumiKimiko Ubukata
Jun 1, 2021·Frontiers in Cellular and Infection Microbiology·Yacui WangAdong Shen
Oct 4, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Huei-Min HungYu-Chia Hsieh
Sep 4, 2021·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Joon Kee LeeEun Hwa Choi

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Methods Mentioned

BETA
PCR
in silico methods

Software Mentioned

MLVA
SPSS
eBURST

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