PMID: 6967053Feb 15, 1980Paper

Clonal extinction of myelomonocytic leukemic cells by serum from mice injected with endotoxin

International Journal of Cancer. Journal International Du Cancer
D Metcalf

Abstract

Culture of WEHI-3B myelomonocytic leukemic cells in semi-solid agar medium containing post-endotoxin serum led to the development of maturing granulocytes and macrophages in most leukemic colonies. Colony size was consistently increased but the colony content of colony-forming cells (stem-cell self-replication) was markedly reduced. Serial recloning of WEHI-3B colony cells in the continuous presence of post-endotoxin serum led to clonal extinction of the leukemic cells in five of seven experiments. These effects of post-endotoxin serum on WEHI-3B cells were not seen in clonal cultures of 10 other tumor lines. Serum with the capacity to induce differentiation in WEHI-3B cells could be induced by the injection of as little as 0.1 microgram endotoxin and by purified bacterial cell-wall preparations. Serum activity reached peak levels 3 - 6 h after endotoxin injection and returned to preinjection levels within 48 h.

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Citations

Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K WelteM A Moore
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H TsudaD H Pluznik
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J L GabriloveM A Moore
Feb 1, 1996·Cancer Biotherapy & Radiopharmaceuticals·A Jakubowski, J Gabrilove
Mar 1, 1987·Blut·E Platzer, J R Kalden
Dec 7, 2010·Best Practice & Research. Clinical Haematology·H Phillip Koeffler
Jan 1, 1983·Leukemia Research·S Glynn, A K Sullivan
Jan 15, 1987·International Journal of Cancer. Journal International Du Cancer·C G BegleyN A Nicola
Nov 15, 1980·International Journal of Cancer. Journal International Du Cancer·A W Burgess, D Metcalf
Jul 15, 1988·International Journal of Cancer. Journal International Du Cancer·R M Böhmer, A W Burgess
Mar 15, 1983·International Journal of Cancer. Journal International Du Cancer·J M HeardB Varet
Jan 1, 1987·Annals of the New York Academy of Sciences·J F DelamarterN M Gough
Dec 15, 1982·International Journal of Cancer. Journal International Du Cancer·D Metcalf, N A Nicola
May 1, 1989·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A W Burgess
Jan 1, 1989·Journal of Cellular Physiology·A B Troutt, F Lee
Jan 1, 1983·Pathology·D Metcalf
May 11, 2001·Japanese Journal of Cancer Research : Gann·R FengM Miwa
Jul 1, 1992·Current Problems in Cancer·G D Demetri
Mar 1, 1984·Immunology Today·N A Nicola, M Vadas
May 22, 1987·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D Metcalf
Jan 1, 1982·Journal of Cellular Physiology. Supplement·D Metcalf
Aug 15, 1982·International Journal of Cancer. Journal International Du Cancer·D Metcalf
Nov 27, 1987·Science·J J Jimenez, A A Yunis

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