Clonal Hematopoiesis: A New Layer in the Liquid Biopsy Story in Lung Cancer

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Joshua Bauml, Benjamin Levy

Abstract

Cell-free DNA (cfDNA) is a unique biospecimen that contains multiple sources of DNA, including tumor, germline, fetal, and others. Clonal hematopoiesis, a process that leads to expansion of mutations in peripheral blood cells, is an additional source of DNA that adds a layer of complexity when interpreting results. Clin Cancer Res; 24(18); 4352-4. ©2018 AACRSee related article by Hu et al., p. 4437.

References

Apr 27, 2017·Nature·Christopher AbboshCharles Swanton
Oct 24, 2017·Annals of Translational Medicine·Melina MarmarelisJoshua Bauml
Mar 6, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jason D MerkerNicholas C Turner
Mar 24, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yuebi HuGeoffrey R Oxnard

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Citations

Oct 31, 2018·Proceedings of the National Academy of Sciences of the United States of America·Peiyong JiangRossa W K Chiu
Apr 16, 2019·Pharmacogenomics·Penn MuluhngwiMark W Linder
Jun 20, 2019·Cancers·Chiang-Ching HuangLiang Wang
Jul 10, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexandra SnyderMatthew D Hellmann
Jan 27, 2021·International Journal of Cancer. Journal International Du Cancer·Ryosuke OkamuraRazelle Kurzrock
Feb 7, 2021·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W YuJ K Skog
Feb 22, 2021·Seminars in Radiation Oncology·Samuel R Jean-BaptisteGary D Kao
Apr 16, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Michael J DuffyJohn Crown
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G SiravegnaA Bardelli
Aug 22, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Colin R LindsayJulien Mazières

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