Clonal Hematopoiesis: A New Step Linking Inflammation to Heart Failure.

JACC. Basic to Translational Science
Yoshimitsu YuraKenneth Walsh

Abstract

Heart failure is a common disease with poor prognosis that is associated with cardiac immune cell infiltration and dysregulated cytokine expression. Recently, the clonal expansion of hematopoietic cells with acquired (i.e., nonheritable) DNA mutations, a process referred to as clonal hematopoiesis, has been reported to be associated with cardiovascular diseases including heart failure. Mechanistic studies have shown that leukocytes that harbor these somatic mutations display altered inflammatory characteristics that worsen the phenotypes associated with heart failure in experimental models. In this review, we summarize recent epidemiological and experimental evidence that support the hypothesis that clonal hematopoiesis-mediated immune cell dysfunction contributes to heart failure and cardiovascular disease in general.

Citations

Aug 5, 2020·Journal of Clinical Medicine·Veronica PapaFrancesco Vieceli Dalla Sega
Dec 3, 2020·Current Oncology Reports·Alessandra CuomoValentina Mercurio
Apr 24, 2021·Trends in Cardiovascular Medicine·Nicholas W ChavkinKenneth Walsh
Jun 7, 2021·Cellular Signalling·Chen GaoYibin Wang
Jun 14, 2021·Revista Española De Cardiología·Laura PalomoAntoni Bayés-Genís

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Methods Mentioned

BETA
exome sequencing
amplicon sequencing
histone acetylation
acetylation

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