Sep 7, 2018

Clonal Hematopoiesis and Its Impact on Cardiovascular Disease

Circulation Journal : Official Journal of the Japanese Circulation Society
Soichi SanoKenneth Walsh


A number of recent epidemiological studies have associated the clonal expansion of hematopoietic cells, a process referred to as clonal hematopoiesis, with increased mortality. Clonal hematopoiesis increases the risk of hematological cancer, but this overall risk cannot account for the increase in mortality in the general population. Surprisingly, these mutations have also been associated with higher rates of cardiovascular disease, suggesting a previously unrecognized link between somatic mutations in hematopoietic cells and chronic disease. Here, we review recent epidemiological and experimental studies on clonal hematopoiesis that relate to cardiovascular disease.

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Mentioned in this Paper

Hematologic Neoplasms
Somatic Mutation
Chronic Disease
Hematopoiesis, Medullary
Cardiovascular Diseases
Epidemiologic Studies
Clonal Expansion
Hematopoietic Cell

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