Clonal identity and differences in primary cutaneous B-cell lymphoma occurring at different sites or time points in the same patient

The American Journal of Dermatopathology
Mika FujiwaraUma Sundram

Abstract

Primary cutaneous B-cell lymphomas (PCBCL) are rare. Marginal zone lymphomas and follicle center lymphomas (FCL) represent a majority of these cases, and a significant number of cases present with multiple lesions. It is unclear whether multiple lesions in PCBCL represent dissemination of a single clone or multiple new primary lymphomas. In the current study, we analyzed paired samples from 20 PCBCL patients at more than 1 site (16) or at the same site at different time points (4) and 12 patients with benign lymphoid infiltrates to investigate for the presence or absence of a clone, and if present, whether the clones were identical. Both IGH@ and IGK@ rearrangements were tested using the BIOMED-2 protocol. We identified a clone (IGH@ and/or IGK@) in 19 of 20 (95%) PCBCL patients and 2 of 12 (17%) benign lymphoid infiltrate patients. The B-cell clones were proven to be identical in 11 of 20 (55%) PCBCL patients, including 7 of 16(44%) biopsies from patients with 2 different sites and 4 of 4 biopsies (100%) from patients at the same site but different time points. In 4 cases (3 FCL and 1 marginal zone lymphoma), different clones were detected at different sites, suggesting the possibility of a second simultaneous primary lymphoma...Continue Reading

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Citations

Dec 6, 2012·Pathology Research International·Philipp W Raess, Adam Bagg
Jun 1, 2014·Surgical Pathology Clinics·Uma Sundram
Apr 22, 2016·Current Hematologic Malignancy Reports·Meenal KheterpalSteven M Horwitz
Aug 20, 2016·Journal of Cutaneous Pathology·Alejandro A GruJohn L Frater
Aug 19, 2020·American Journal of Clinical Pathology·Sarah E Gibson, Steven H Swerdlow

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