Clonal integration of a polyomavirus in human Merkel cell carcinoma.

Science
Huichen FengPatrick S Moore

Abstract

Merkel cell carcinoma (MCC) is a rare but aggressive human skin cancer that typically affects elderly and immunosuppressed individuals, a feature suggestive of an infectious origin. We studied MCC samples by digital transcriptome subtraction and detected a fusion transcript between a previously undescribed virus T antigen and a human receptor tyrosine phosphatase. Further investigation led to identification and sequence analysis of the 5387-base-pair genome of a previously unknown polyomavirus that we call Merkel cell polyomavirus (MCV or MCPyV). MCV sequences were detected in 8 of 10 (80%) MCC tumors but only 5 of 59 (8%) control tissues from various body sites and 4 of 25 (16%) control skin tissues. In six of eight MCV-positive MCCs, viral DNA was integrated within the tumor genome in a clonal pattern, suggesting that MCV infection and integration preceded clonal expansion of the tumor cells. Thus, MCV may be a contributing factor in the pathogenesis of MCC.

References

Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G WalterM Mumby
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M DürstH zur Hausen
Dec 26, 2001·Bioinformatics·H H Chou, M H Holmes
Feb 21, 2002·Lancet·Eric A EngelsRobert W Miller
Jun 1, 1953·Proceedings of the Society for Experimental Biology and Medicine·L GROSS
Apr 22, 2006·Advances in Experimental Medicine and Biology·Keith A CrandallRaphael P Viscidi
Sep 12, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Danielle L Poulin, James A DeCaprio
Feb 9, 2007·Journal of Virology·Tobias AllanderBjörn Andersson
Aug 19, 2007·The Journal of Investigative Dermatology·Bianca Lemos, Paul Nghiem

❮ Previous
Next ❯

Citations

Dec 20, 2008·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A WiechertJ Wenzel
Mar 20, 2009·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·U PippirsK W Schulte
Apr 22, 2009·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M WosnitzaM Megahed
Dec 17, 2008·Der Pathologe·I Petersen, F Klein
Jan 1, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Tatyana Milman, Steven A McCormick
May 27, 2011·Medical Microbiology and Immunology·Diana V PastranaHerbert Pfister
Sep 25, 2012·Medical Microbiology and Immunology·Carla Cerqueira, Mario Schelhaas
Mar 20, 2010·Archives of Virology·Anna L VestergaardAnnika Antonsson
Jun 22, 2010·Archives of Virology·Massimo CiccozziMarco Ciotti
May 13, 2011·Archives of Virology·Reimar JohneLeonard C Norkin
Feb 19, 2013·Archives of Virology·Xiangning ZhangIngemar Ernberg
Jun 26, 2013·Wiener medizinische Wochenschrift·José Carlos CardosoUwe Wollina
Aug 23, 2011·Cancer Causes & Control : CCC·Valeria AscoliSusanna Conti
Jul 30, 2010·Journal of Neuro-oncology·Thomasina L BaileyRudolph J Schrot
Jun 1, 2011·Virus Genes·Chi-Fang ChangDeching Chang
Apr 20, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Leslie J Marshall, Eugene O Major
Feb 26, 2013·Current Treatment Options in Oncology·Natalie J MillerPaul Nghiem
Aug 9, 2008·Current Infectious Disease Reports·Camille Nelson Kotton
May 29, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Isabel Prieto MuñozAna M Pérez Casas
Dec 18, 2012·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Sine HadrupPer Thor Straten
Jun 7, 2013·Aging Clinical and Experimental Research·C UltoriC Capella
Nov 5, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Cecilia LindauTobias Allander
Mar 23, 2013·Journal of Dermatological Science·Tomoyasu HattoriOsamu Ishikawa
Oct 15, 2013·The Journal of Infection·Michelle Pinto, Simon Dobson
Dec 19, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Mengtao LiYi-Ling Lin
Apr 16, 2013·Lancet·Paul FineAngus Deaton
Dec 1, 2008·Annales de dermatologie et de vénéréologie·P Humbert
Mar 3, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Eric J DuncavageJohn D Pfeifer
May 18, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Heli M KukkoTom O Böhling
Jul 19, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sofia AsioliGianni Bussolati
May 10, 2011·Nature Biotechnology·Aleksandar D KosticMatthew Meyerson
Oct 3, 2013·Nature Communications·Ka-Wei TangErik Larsson
Nov 26, 2010·Nature Reviews. Cancer·Patrick S Moore, Yuan Chang
Nov 24, 2012·Nature Reviews. Cancer·Lawrence BanksMiranda Thomas
Feb 28, 2009·Nature Reviews. Drug Discovery·William N WilliamScott M Lippman
Mar 12, 2013·Nature Reviews. Microbiology·James A DeCaprio, Robert L Garcea
Jan 27, 2010·Oncogene·A F Fernandez, M Esteller
Jul 8, 2008·Médecine sciences : M/S·Jean Kanitakis
Oct 10, 2008·The New England Journal of Medicine·Bianca D LemosPaul Nghiem
Aug 9, 2013·The New England Journal of Medicine·Ami S BhattMatthew Meyerson
Sep 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Masahiro ShudaYuan Chang
Nov 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Amit KapoorEric Delwart
Oct 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Harald zur Hausen
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Andrew RouthJohn E Johnson

❮ Previous
Next ❯

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