PMID: 8982050Dec 1, 1996Paper

Clonal involvement of eosinophils in therapy-related myelodysplastic syndrome with eosinophilia, translocation t(1;7) and lung cancer

British Journal of Haematology
Y ImaiA Takahashi

Abstract

We report a therapy-related MDS (RAEB) patient with eosinophilia, unbalanced translocation der(7)t(1;7) (q12;q22) and lung cancer. We observed no increase in cytokine levels in serum or in the conditioned medium (CM) of peripheral T cells cultured with or without IL-2. When bone marrow (BM) cells were cultured with GM-CSF, IL-3 and SCF in a semisolid system, the colonies were exclusively eosinophilic. Cytogenetic analysis of the colony cells identified the same chromosome abnormality in all metaphases to that of BM cells. Suspension and clonogenic colony assay of BM cells cultured with various cytokines showed predominant eosinophilic growth and differentiation with GM-CSF, but not with the other cytokines examined. These findings, together with mild morphological abnormalities of eosinophils, indicate clonal involvement of eosinophils in the myelodysplastic syndrome (MDS) clone, and that the eosinophilia was derived from the neoplastic clone with the translocation and was not associated with the patient's lung cancer.

Citations

Apr 3, 2007·The Journal of Allergy and Clinical Immunology·Dagmar Simon, Hans-Uwe Simon
Apr 16, 2003·British Journal of Haematology·Finella Brito-Babapulle
Jul 9, 2003·British Journal of Haematology·Barbara J Bain
Nov 25, 1997·Blood Reviews·F Brito-Babapulle

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