PMID: 6972356Nov 15, 1980Paper

Clonal regulation of the induction of macrophage-and granulocyte-inducing proteins for normal and leukemic myeloid cells

International Journal of Cancer. Journal International Du Cancer
A Falk, L Sachs

Abstract

A cloned line of myeloid leukemic cells can be induced by the alkylating agent nitrosoguanidine for two macrophage- and granulocyte-inducing (MGI) activities. One activity, MGI-I, induced the formation of macrophage and granulocyte colonies from normal myeloblasts. Another activity, MGI-2, induced differentiation of MGI+D+ myeloid leukemic cells to macrophages and granulocytes. Experiments on the time course of induction of the two activities have shown that MGI-I was induced before MGI-2, MGI-1 was first detected in cell extracts and this was followed by detection of both activities in culture supernatants (conditioned medium). After induction with bacterial lipopolysaccharide, another inducer of both MGI activities in this clone, MGI-I was also detected before MGI-2 in cell extracts. The steroid dexamethasone, which is an effective inducer of some differentiation-associated properties in this clone, did not induce either MGI-1 or MGI-2. Studies with different clones of myeloid leukemic cells have shown a clonal variation in the induction of MGI-1 and MGI-2. Different clones were induced by nitrosoguanidine either for MGI-1 and MGI-2, for MGI-1 without MGI-2, or for neither MGI-1 nor MGI-2. None of the clones were induced for ...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J Lotem, L Sachs
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·B Weiss, L Sachs
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J Lotem, L Sachs
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J Lotem, L Sachs
Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J I Toohey
May 15, 1975·International Journal of Cancer. Journal International Du Cancer·J Lotem, L Sachs
Dec 1, 1969·Journal of Cellular Physiology·Y Ichikawa
Feb 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·E FibachL Sachs
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J Lotem, L Sachs
May 1, 1974·The Journal of Experimental Medicine·S GordonZ A Cohn
Aug 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·Y IchikawaL Sachs
Oct 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·Y IchikawaL Sachs
Nov 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·M ParanP Resnitzky
Dec 1, 1965·Journal of Cellular Physiology·D H Pluznik, L Sachs
Oct 1, 1966·Experimental Cell Research·D H Pluznik, L Sachs
Jun 15, 1980·International Journal of Cancer. Journal International Du Cancer·J LotemL Sachs

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Citations

Jan 1, 1986·Advances in Enzyme Regulation·A C SartorelliM Reiss
Dec 15, 1983·International Journal of Cancer. Journal International Du Cancer·J Lotem, L Sachs
Jul 15, 1983·International Journal of Cancer. Journal International Du Cancer·J Lotem, L Sachs
Feb 15, 1982·International Journal of Cancer. Journal International Du Cancer·D LiebermannL Sachs
Sep 15, 1981·International Journal of Cancer. Journal International Du Cancer·J Lotem, L Sachs
Dec 15, 1982·International Journal of Cancer. Journal International Du Cancer·D Metcalf, N A Nicola
Aug 15, 1982·International Journal of Cancer. Journal International Du Cancer·D Metcalf
Jan 15, 1984·International Journal of Cancer. Journal International Du Cancer·J Lotem, L Sachs
Aug 21, 1987·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·L Sachs
Dec 1, 1986·Cell Biophysics·L Sachs
Sep 1, 1987·Molecular and Cellular Biology·M AzoulayL Sachs

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