Clonal relatedness of enterotoxigenic Escherichia coli strains isolated from a cohort of young children in Guinea-Bissau

Journal of Clinical Microbiology
Hans SteinslandHalvor Sommerfelt

Abstract

In a cohort study of 200 young children in Guinea-Bissau, it was previously found that some enterotoxigenic Escherichia coli (ETEC) strains were more pathogenic than others, depending on the type of toxin that they could produce, and that natural ETEC infections induced substantial protection against new infections with ETEC strains that had the same combination of toxins and colonization factors (CFs). We wanted to describe the clonal relatedness of the ETEC strains isolated during this study and to investigate whether the protective antigens and the virulence factors that were responsible for the pathogenic traits were common to strains that were clonally closely related or whether they were more likely to be encoded by the ETEC virulence plasmids that normally encode the toxins and the CFs. By performing repetitive sequence-based PCR analysis of strains representing 452 infections, we found that strains that had the same toxin-CF profile were usually closely related, although a few were unrelated. Strains that did not have the same toxin-CF profiles but that were positive for a given toxin or for a given CF were not consistently more closely related to each other than to strains that were negative for the same toxin or CF. O...Continue Reading

References

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Nov 26, 2002·The Journal of Infectious Diseases·Hans SteinslandHalvor Sommerfelt
Mar 5, 2003·Diagnostic Microbiology and Infectious Disease·Hans SteinslandHalvor Sommerfelt

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Citations

Apr 20, 2011·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Claudia RodasVolga Iniguez
Jun 11, 2010·Journal of Clinical Microbiology·Hans SteinslandThomas S Whittam
Apr 11, 2014·Journal of Pathogens·Lisa M RuncoJ Robert Coleman
Jul 21, 2010·Journal of Microbiological Methods·Ulf SommerChristian Morsczeck
Jun 18, 2014·Infection and Immunity·Alaullah SheikhJames M Fleckenstein

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