Clonal relationship between closely approximated low-grade ductal and lobular lesions in the breast: a molecular study of 10 cases

American Journal of Clinical Pathology
Patrick L WagnerSandra J Shin

Abstract

The relationship between ductal and lobular breast carcinoma is highlighted in cases in which these morphologically divergent carcinomas coexist in proximity within a single patient. We hypothesized that such cases may result from the proliferation of a precursor lesion into a tumor containing areas of divergent morphologic features. In this study, we analyzed loss of heterozygosity (LOH) in 10 cases of coexistent ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS), and invasive carcinoma. DNA from the separate components of each lesion was subjected to LOH analysis using 13 markers on 7 chromosomes. In 7 cases, the DCIS and LCIS shared loss of a common allele, suggesting a clonal relationship. The invasive component shared loss of the same allele in 5 tumors. This finding indicates that coexistent lobular and ductal carcinomas exhibit shared genetic abnormalities, contradicting the conventional concept that these lesions represent separate, exclusive pathways of breast neoplasia. Instead, these traditionally segregated classes of breast cancer may, in fact, share common precursor lesions.

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Citations

Nov 15, 2011·Breast Cancer Research and Treatment·Mary MorroghTari A King
Jul 11, 2012·Breast Cancer Research : BCR·Victor P AndradeTari A King
Jun 24, 2016·Breast Cancer Research : BCR·Colin B BeggTari A King
Mar 18, 2017·Scientific Reports·Denggang FuBrian Z Ring
Jan 19, 2018·The Journal of Pathology·Amy E McCart ReedPeter T Simpson
Nov 18, 2015·Applied Immunohistochemistry & Molecular Morphology : AIMM·Aparna HarbhajankaPaolo Gattuso
Jun 21, 2013·Pathology International·Eri TazakiHiroshi Kamma
Jul 3, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Christos PetridisElinor J Sawyer
Sep 7, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ju Youn LeeTari A King
Feb 8, 2018·Surgical Pathology Clinics·Hannah Y Wen, Edi Brogi

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