Clonal Spread of Tetracycline Resistance Among Mycoplasma hominis Clinical Strains, Tunisia

Infection and Drug Resistance
Safa BoujemaaBoutheina Ben Abdelmoumen Mardassi

Abstract

Antimicrobial resistance in a number of bacterial pathogens has been shown to spread clonally. To our knowledge, data about the phylodistribution of drug resistance in Mycoplasma hominis are very scarce. The aims of this study were to assess the antimicrobial susceptibility of Mycoplasma hominis clinical strains in Tunisia, to identify the molecular basis of antibiotic resistance, and to investigate the phylogenetic relationships of resistant strains. This study included 65 molecularly typed Mycoplasma hominis clinical strains recovered from Tunisian patients over 18 years (2000-2018). The antimicrobial susceptibility was tested against nine antibacterial agents using the broth microdilution method. Minimum spanning tree was constructed to establish the phylogenetic relationships among resistant isolates. Fluoroquinolones, doxycycline, and josamycine were found to be the most effective antibacterial agents. However, 22 strains belonging to 11 expanded multilocus sequence types (eSTs) proved resistant to tetracycline. The majority of these eSTs were genetically related, indicative of clonal expansion of tetracycline resistance. The present study provides relevant information on the antibiotic susceptibility of Tunisian M. homini...Continue Reading

References

Dec 26, 2008·Seminars in Fetal & Neonatal Medicine·Ken B WaitesMiles J Novy
Nov 21, 2017·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Urszula KasprzykowskaGrażyna Gościniak
Jan 31, 2020·Antimicrobial Resistance and Infection Control·Safa BoujemaaBoutheina Ben Abdelmoumen Mardassi
Feb 1, 2020·Antimicrobial Resistance and Infection Control·Safa BoujemaaBoutheina Ben Abdelmoumen Mardassi

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Datasets Mentioned

BETA
ER1709
CP030240.1

Methods Mentioned

BETA
PCR

Software Mentioned

BioNumerics
eMLST
BioEdit

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