Clonal variation in high- and low-level phenotypic and genotypic mupirocin resistance of MRSA isolates in south-east London

The Journal of Antimicrobial Chemotherapy
John HughesOlga Tosas Auguet

Abstract

Both low-level mupirocin resistance (LMR) and high-level mupirocin resistance (HMR) have been identified. The aim of this study was to determine the epidemiology of LMR and HMR in MRSA isolates at five hospitals that have used mupirocin for targeted decolonization as part of successful institutional control programmes. All MRSA identified in three microbiology laboratories serving five central and south-east London hospitals and surrounding communities between November 2011 and February 2012 were included. HMR and LMR were determined by disc diffusion testing. WGS was used to derive multilocus sequence types (MLSTs) and the presence of HMR and LMR resistance determinants. Prevalence of either HMR or LMR amongst first healthcare episode isolates from 795 identified patients was 9.69% (95% CI 7.72-11.96); LMR was 6.29% (95% CI 4.70-8.21) and HMR was 3.40% (95% CI 2.25-4.90). Mupirocin resistance was not significantly different in isolates identified from inpatients at each microbiology laboratory, but was more common in genotypically defined 'hospital' rather than 'community' isolates (OR 3.17, 95% CI 1.36-9.30, P = 0.002). LMR was associated with inpatient stay, previous history of MRSA and age ≥65 years; HMR was associated with...Continue Reading

References

Nov 18, 1998·The Journal of Antimicrobial Chemotherapy·F J SchmitzM E Jones
Mar 4, 1999·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·S TorvaldsenT V Riley
Aug 5, 2000·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·J E VasquezF A Sarubbi
Nov 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S HarbarthD Pittet
Jan 11, 2001·The Journal of Antimicrobial Chemotherapy·J WiströmB Svenungsson
Jun 6, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Elaine S WalkerFelix A Sarubbi
Apr 4, 2006·The Journal of Hospital Infection·J E CoiaUNKNOWN Infection Control Nurses Association
Apr 18, 2007·Antimicrobial Agents and Chemotherapy·Daniel G DriscollUrs A Ochsner
Aug 9, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeffrey C JonesDavid K Warren
Mar 20, 2008·Genome Research·Daniel R Zerbino, Ewan Birney
Sep 24, 2008·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Kanokporn MongkolrattanothaiBarry Gray
Mar 6, 2009·Genome Biology·Ben LangmeadSteven L Salzberg
Jun 6, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Ari RobicsekLance R Peterson
Aug 14, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jean B PatelJohn A Jernigan
Dec 17, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rahul BatraJonathan D Edgeworth
Dec 26, 2009·The Journal of Antimicrobial Chemotherapy·Matthew J EllingtonAlan P Johnson
Sep 18, 2010·The Journal of Hospital Infection·A R CaffreyK L LaPlante
Jun 2, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andie S LeeStephan Harbarth
Dec 22, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Clare E MillerJonathan D Edgeworth
Jan 19, 2012·Antimicrobial Agents and Chemotherapy·Christine SeahRoberto G Melano
May 25, 2012·The Journal of Hospital Infection·J A Otter, G L French
Jul 4, 2012·Autism : the International Journal of Research and Practice·Jessica R DykstraSam L Odom
Nov 14, 2012·Antimicrobial Agents and Chemotherapy·Stephanie A FritzCarey-Ann D Burnham
May 31, 2013·The New England Journal of Medicine·Susan S HuangUNKNOWN AHRQ DECIDE Network and Healthcare-Associated Infections Program
Oct 23, 2013·The Journal of Hospital Infection·D J Hetem, M J M Bonten
Aug 15, 2014·Journal of Clinical Microbiology·Andie S LeePatrice François
Sep 5, 2015·The Journal of Antimicrobial Chemotherapy·Sarah R DeenyJulie V Robotham

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Citations

Dec 1, 2015·AORN Journal·Kathy AuredenFrank Myers
Feb 26, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sarah R DeenyJulie V Robotham
Sep 5, 2015·The Journal of Antimicrobial Chemotherapy·Sarah R DeenyJulie V Robotham
Feb 6, 2019·Antibiotics·Peter Mantle
Aug 28, 2018·Antimicrobial Resistance and Infection Control·Adebayo O ShittuAyodele O Olatimehin
Aug 15, 2019·Implementation Science : IS·Nina Van GoethemAnnie Robert

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