Clonality analysis of T cells mediating acute and chronic rejection in kidney allografts

Transplant Immunology
F ObataS Baba

Abstract

The clonality of T-cell populations mediating acute and chronic rejection (AR and CR, respectively) of kidney allografts was ascertained by investigating the diversity of TCRBV genes expressed by allograft-infiltrating T cells. Both oligoclonality and polyclonality cases were found in biopsy specimens of AR as well as CR. These results indicated that the T-cell clonality in each specimen did not correlate directly with the mode of rejection. When AR and CR specimens were compared, however, the CR specimen group was significantly more polyclonal (or less oligoclonal) than the AR group. This result may reflect the higher chance of epitope spreading in the more slowly progressing CR than in AR.

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Citations

May 14, 2011·Journal of the American Society of Nephrology : JASN·Rajani DinavahiPeter S Heeger
Apr 30, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Uwe Heemann, Jens Lutz
Jul 22, 2008·Human Immunology·Peter Boros, Jonathan S Bromberg
Aug 22, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Sonia Y VelásquezCristiam M Alvarez
May 30, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Anthony J Demetris, Mylene Sebagh
Apr 27, 2013·Current Opinion in Organ Transplantation·Anthony J Demetris, Kumiko Isse

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