Clonality and life cycles of intestinal crypts explained by a state dependent stochastic model of epithelial stem cell organization

Journal of Theoretical Biology
M LoefflerC S Potten

Abstract

The organization and control of stem cells is a key issue in epithelial cell biology. The small intestinal murine crypt is a useful tissue to study such problems since stem cells are known to be located at specific positions at the bottom of the crypt where they are self maintaining. Recent data suggest, that (1) the number of active stem cells in a crypt can fluctuate, (2) the immediate progeny of a single stem cell can replace other stem cells eventually leading to monoclonality and (3) the life cycle of crypts may be linked to stem cell dynamics. It is the objective of this paper to suggest a stochastic state-dependent model of stem cell and crypt growth which can explain and-link these phenomena into one comprehensive framework. Monte Carlo simulations are performed to show consistently with available data. The model explains the size distribution of small intestinal crypts in steady state, the observations of stem cell fluctuations and monoclonality conversion, recovery of the crypt population after moderate damage and the rate of crypt fission and extinction. The key assumption of this model is an autoregulatory control of stem cell growth.

Citations

Nov 13, 2008·Cytotechnology·Sowmya Viswanathan, Peter W Zandstra
Oct 12, 2010·Science·Carlos Lopez-GarciaDouglas J Winton
Jan 2, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Aaron P GarrisonMichael A Helmrath
Dec 18, 2008·Future Oncology·Trevor A Graham, Nicholas A Wright
Aug 10, 2011·Future Oncology·Trevor A GrahamNicholas A Wright
Jan 31, 2012·Journal of Theoretical Biology·Alexander G FletcherS Jonathan Chapman
Feb 12, 2004·Cell Proliferation·M Brittan, N A Wright
Nov 26, 2008·The Journal of Pathology·D Shibata
May 5, 2006·Cell Proliferation·I M M van LeeuwenJ R King
Mar 23, 2011·Stem Cells·Jorge MúneraRobert G Oshima
Oct 1, 2009·Cell Proliferation·C S PottenN A Wright
Oct 31, 2014·PloS One·Jan Christian KaiserPeter Jacob
May 26, 2012·The Journal of Surgical Research·Erin E PerroneEric D Strauch
Dec 13, 2005·Journal of Molecular Biology·Yuefeng TangDaniel P Raleigh
Jul 14, 2010·Journal of Pediatric Surgery·Erin E PerroneEric D Strauch
Feb 9, 2017·Nature Reviews. Gastroenterology & Hepatology·Chang-Ho R ChoiTrevor A Graham
Dec 30, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Carmen PinToshiro Sato
Apr 15, 2006·Digestive Diseases and Sciences·Adrian G CumminsFiona M Thompson
Mar 16, 2007·Digestive Diseases and Sciences·Kimberley S CamacAdrian G Cummins
May 16, 2008·Nature Reviews. Cancer·Adam Humphries, Nicholas A Wright
Jul 31, 2008·Journal of Pediatric Gastroenterology and Nutrition·Adrian G CumminsFiona M Thompson
Aug 15, 2015·The EMBO Journal·Elise S DemitrackLinda C Samuelson
May 25, 2002·In Vitro Cellular & Developmental Biology. Animal·Bertrand Kaeffer
Jan 21, 2006·World Journal of Gastroenterology : WJG·Wei ChenZhi-Yong Sheng
Mar 10, 1999·The American Journal of Physiology·C M CoopersmithJ I Gordon
Mar 27, 2003·The Journal of Biological Chemistry·Véronique PonsAma Gassama-Diagne
Mar 20, 2010·Biochemical Society Transactions·Kirill Pavlov, Carlo C Maley
Nov 6, 2018·Frontiers in Immunology·Ibrahim Al BakirTrevor A Graham
Dec 24, 2011·Journal of Pediatric Gastroenterology and Nutrition·Jane K FauserAdrian G Cummins
Nov 25, 2003·The Journal of Biological Chemistry·Véronique PonsFrançoise Hullin-Matsuda
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·P G FalkJ I Gordon

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