Clonality of combined tumors.

Archives of Pathology & Laboratory Medicine
Jiaoti HuangJaishree Jagirdar

Abstract

Tumors with mixed morphologic patterns (combined tumors) are sometimes encountered, and questions often arise regarding the mechanism of molecular pathogenesis of each component and their relationships. To determine whether different components of combined tumors contain the same or different genetic alterations, thus providing evidence for their clonality. Six combined tumors with 2 components (in each case, both components showed epithelial differentiation morphologically) were studied by microdissecting tumor cells from each morphologic area followed by loss of heterozygosity analysis. In 1 of the cases studied, the different morphologic areas contained different patterns of genetic alterations. In the remaining 5 cases, the different morphologic areas harbored identical genetic changes in the chromosome regions studied. The latter group, interestingly, included a colonic tumor with an area of tubulovillous adenoma and an area of neuroendocrine carcinoma, and 2 lung tumors with squamous carcinoma and small cell carcinoma components. Our results suggest that in the majority of combined tumors, cells with different phenotypes share similar genotype and may arise from a single precursor cell. However, in a minority of these tum...Continue Reading

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Oct 19, 2006·Pathology, Research and Practice·Keiichi IezumiToshiyuki Mitsuya
Aug 9, 2007·Virchows Archiv : an International Journal of Pathology·Marco VolanteMauro Papotti
Jan 22, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tiziana D'AddaCesare Bordi
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