Abstract
Tumors with mixed morphologic patterns (combined tumors) are sometimes encountered, and questions often arise regarding the mechanism of molecular pathogenesis of each component and their relationships. To determine whether different components of combined tumors contain the same or different genetic alterations, thus providing evidence for their clonality. Six combined tumors with 2 components (in each case, both components showed epithelial differentiation morphologically) were studied by microdissecting tumor cells from each morphologic area followed by loss of heterozygosity analysis. In 1 of the cases studied, the different morphologic areas contained different patterns of genetic alterations. In the remaining 5 cases, the different morphologic areas harbored identical genetic changes in the chromosome regions studied. The latter group, interestingly, included a colonic tumor with an area of tubulovillous adenoma and an area of neuroendocrine carcinoma, and 2 lung tumors with squamous carcinoma and small cell carcinoma components. Our results suggest that in the majority of combined tumors, cells with different phenotypes share similar genotype and may arise from a single precursor cell. However, in a minority of these tum...Continue Reading
References
Aug 16, 1995·Journal of the National Cancer Institute·Y KishimotoA F Gazdar
Dec 1, 1994·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·T EnomotoK R Shroyer
Feb 25, 1994·Nucleic Acids Research·L BusqueD G Gilliland
Apr 1, 1996·Human Pathology·I I WistubaJ Albores-Saavedra
Mar 1, 1996·The American Journal of Surgical Pathology·L ThompsonS H Barsky
Jul 1, 1996·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K Sakata
Nov 1, 1996·Human Pathology·Y YamamotoA F Gazdar
Nov 1, 1996·The Laryngoscope·L L GleichJ L Gluckman
Jan 28, 1998·Human Pathology·S KounelisS D Finkelstein
May 30, 1998·JAMA : the Journal of the American Medical Association·I I WistubaA F Gazdar
Jan 6, 2000·Japanese Journal of Cancer Research : Gann·S NihoK Mukai
Jul 25, 2000·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A M KersemaekersG J Fleuren
Oct 3, 2000·Human Pathology·H FujiiT Shirai
Dec 21, 2000·Cancer Letters·F PuglisiC Di Loreto
Citations
Feb 13, 2003·Medical Hypotheses·Lawrence M Agius
Aug 19, 2004·The American Journal of Surgical Pathology·Giulio RossiGabriele Luppi
Nov 17, 2005·Pathology International·Mitsuhiro FukushimaTeruaki Koike
Jul 28, 2005·International Journal of Experimental Pathology·Bo HanKennichi Kakudo
Oct 19, 2006·Pathology, Research and Practice·Keiichi IezumiToshiyuki Mitsuya
Aug 9, 2007·Virchows Archiv : an International Journal of Pathology·Marco VolanteMauro Papotti
Jan 22, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tiziana D'AddaCesare Bordi
Jun 1, 2006·Annales de pathologie·Valérie Hervieu, Jean-Yves Scoazec
Jun 14, 2008·Virchows Archiv : an International Journal of Pathology·Giovanni FellegaraGuido Rindi
Jan 31, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Timon P H BuysMing-Sound Tsao