Clonality studies in giant cell tumor of bone

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
H S SchwartzM G Butler

Abstract

Genetic studies including chromosome analysis, telomere reduction and telomere activity, DNA microsatellites and loss of heterozygosity (LOH) studies have been performed on giant cell tumor (GCT) of bone however whether this primary skeletal neoplasm represents a monoclonal or polyclonal proliferation is unknown. Utilizing a new assay to study the polymorphic human androgen receptor locus (HUMARA), the ratio of maternal inactive X-chromosome to the paternal inactive X (Lyon hypothesis) is determined via a methylation--specific polymerase chain reaction (PCR) technique to detect X-chromosome polymorphisms. Characterization of the genetic tumorigenesis of this unpredictable neoplasm may lend insight into its biological behavior and offer improvements in therapeutic intervention, as new information emerges regarding osteoclastic bone resorption. Seventeen female patients with giant cell tumor of bone had their DNA harvested and their X-chromosome inactivation pattern and polymorphisms determined and compared to control. A polyclonal proliferation pattern was identified in all informative samples studied.

References

Mar 1, 1995·Cancer·H S SchwartzM G Butler
Dec 1, 1993·Cancer Genetics and Cytogenetics·H S SchwartzM G Butler
May 1, 1996·Cancer Genetics and Cytogenetics·M ScheinerM G Butler
Jul 1, 1997·Human Pathology·G S VogrincicC B Gilks

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Citations

Dec 12, 2012·International Journal of Oncology·Carol Po Ying LauShekhar Madhukar Kumta
Apr 16, 2009·Der Pathologe·F GrabellusK W Schmid
Nov 1, 2006·Cancer Genetics and Cytogenetics·Lance KlinglerHerbert S Schwartz
Mar 31, 2005·Cancer Genetics and Cytogenetics·Uma N M RaoSydney Finkelstein
Jun 6, 2014·Cancer Science·Mika Kato KanekoYukinari Kato
Oct 25, 2012·Case Reports in Medicine·Paul BorbasOskar A Haas
Oct 27, 2010·Brazilian Dental Journal·Fabrício Rezende AmaralRicardo Santiago Gomez
Jun 5, 2007·Clinical Orthopaedics and Related Research·Steven A LietmanMichael A Levine
Feb 19, 2008·The Journal of Pathology·R G ForsythP C W Hogendoorn
Jun 26, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Linda MoskovszkyAdrienne Flanagan
Jun 20, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel G BranstetterIra Jacobs

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