Clonally expanded T-cells in the peripheral blood of patients with idiopathic Thrombocytopenic purpura and Helicobacter pylori infection

International Journal of Hematology
Midori IshiyamaToshiko Motoji

Abstract

Eradication of Helicobacter pylori leads to platelet recovery in some patients with idiopathic thrombocytopenic purpura (ITP). Therefore, the pathogenesis of a subgroup of ITP is probably associated with H pylori infection (H pylori-related ITP). If H pylori-related ITP is a definite subgroup of ITP, specific oligoclonal T-cells might accumulate in the peripheral blood (PB). To address this issue, we performed single-strand conformation polymorphism analysis of complementarity-determining region 3 (CDR3) of the T-cell receptor beta-chain genes of PB T-cells. Fourteen ITP patients with H pylori infection and 12 ageadjusted healthy volunteers were studied. Of the 14 patients, 8 patients (responders) exhibited a platelet response after successful H pylori eradication therapy, but 6 patients (nonresponders) did not. Vbeta5.2, Vbeta15, and Vbeta19 gene usage by clonally expanded T-cells in PB obtained before H pylori eradication therapy was significantly higher in responders than in nonresponders or healthy volunteers (Vbeta5.2, P = .023; Vbeta15, P = .004; Vbeta19, P = .036). Furthermore, an abrogation of clonally expanded T-cells was observed after therapy in some responders. These findings suggest that specific T-cell clones accu...Continue Reading

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Citations

Nov 16, 2006·Current Gastroenterology Reports·Karen J GoodmanKathleen P Ismond
Feb 6, 2008·La Presse médicale·Jean-Dominique de Korwin
Jun 21, 2012·Journal of Digestive Diseases·Huck-Joo Tan, Khean-Lee Goh
Mar 23, 2010·Helicobacter·Masahiro AsakaUNKNOWN Japanese Society for Helicobacter Research
Oct 4, 2014·World Journal of Gastroenterology : WJG·Germán Campuzano-Maya
Sep 28, 2012·European Journal of Gastroenterology & Hepatology·Zeynal DoğanErdem Akbal
Dec 16, 2006·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Kingo Fujimura
Oct 8, 2008·The Medical Journal of Australia·Vanaja SivapathasingamRobert B Wilson

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