Clonazepam for treatment of sleep disturbances associated with combat-related posttraumatic stress disorder

The Annals of Pharmacotherapy
Marshall E CatesThomas W Woolley

Abstract

Clonazepam is widely used for the treatment of posttraumatic stress disorder (PTSD)-related sleep disturbances despite very limited published data supporting its use for this indication. We conducted a pilot-controlled trial to provide more data on this clinical practice and lay the foundation for more definitive studies. The study was designed as a randomized, single-blind (ie, patient only), placebo-controlled, crossover clinical trial involving administration of clonazepam 1 mg at bedtime for one week followed by 2 mg at bedtime for one week. The following week served as a washout period before the alternate treatment was begun. Patients completed sleep diaries each morning upon awakening throughout the study. Parameters included quantity of sleep, quality of sleep, frequency and intensity of difficulty falling or staying asleep, and frequency and intensity of recurrent distressing dreams. Six patients with combat-related PTSD participated in the study. There were no statistically significant differences between clonazepam and placebo for any measure, although clonazepam therapy resulted in mild to moderate numeric improvements in difficulty falling or staying asleep. Adverse effects of clonazepam were generally mild and ess...Continue Reading

References

Jan 1, 1989·The American Journal of Psychiatry
Jan 1, 1995·The American Journal of Psychiatry·T A MellmanB Nolan
Apr 29, 1999·International Clinical Psychopharmacology·R HidalgoJ Davidson
Aug 5, 2000·The Annals of Pharmacotherapy·M Cyr, M K Farrar
Aug 6, 2000·The Journal of Nervous and Mental Disease·T R KostenR Rosenheck
Feb 5, 2002·Expert Opinion on Pharmacotherapy·L L DavisF Petty
Feb 4, 2003·The American Journal of Psychiatry·Murray A RaskindMiles M McFall

❮ Previous
Next ❯

Citations

Aug 3, 2011·Depression Research and Treatment·Hervé JavelotMichaël Messaoudi
Oct 11, 2012·European Journal of Psychotraumatology·Saskia van Liempt
Jun 4, 2014·International Review of Psychiatry·Michael R NadorffAnne Germain
Jul 28, 2012·Expert Opinion on Investigational Drugs·Christopher K CainJohn H Kehne
Feb 10, 2016·Human Psychopharmacology·Gosia LipinskaKevin G F Thomas
Jul 9, 2011·Neuropharmacology·Thomas Steckler, Victoria Risbrough
Sep 8, 2010·Neurologic Clinics·Hrayr Attarian
Feb 18, 2010·Sleep Medicine Clinics·Brant Hasler, Anne Germain
Aug 8, 2006·Annals of the New York Academy of Sciences·Saskia van LiemptHerman Westenberg
Apr 1, 2009·Brain Research·Lakshmi N Ravindran, Murray B Stein
Apr 22, 2008·Sleep Medicine Reviews·Victor I Spoormaker, Paul Montgomery
Nov 26, 2015·The Psychiatric Clinics of North America·Elaine M Boland, Richard J Ross
Apr 22, 2015·Current Psychiatry Reports·Janeese A BrownlowRichard J Ross
Apr 5, 2014·European Journal of Pharmacology·Hendrikus HendriksenRonald S Oosting
Dec 22, 2016·Journal of Clinical Medicine·Mark B DetweilerBrian W Lutgens
Mar 10, 2017·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Macgregor MontañoKathleen Sherrieb
Jan 1, 2009·Expert Review of Clinical Pharmacology·Christopher P AldermanAnita C Marwood
Feb 1, 2017·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Vladan Starcevic
Feb 2, 2018·Journal of Clinical Medicine·Jeffrey Guina, Brian Merrill
May 12, 2006·International Clinical Psychopharmacology·Saskia van LiemptHerman G M Westenberg
Jul 15, 2015·Journal of Psychiatric Practice·Jeffrey GuinaRandon S Welton
Feb 23, 2019·Expert Opinion on Pharmacotherapy·Morohunfolu Akinnusi, Ali A El Solh
Apr 27, 2019·Sleep & Breathing = Schlaf & Atmung·Ali A El-SolhChathura Wijewardena
Dec 21, 2019·The Mental Health Clinician·Megan Ehret
Sep 15, 2020·Health Technology Assessment : HTA·Hollie MeltonPeter Coventry
Jan 19, 2019·Current Sleep Medicine Reports·Tara D RachakondaMiranda M Lim
Nov 24, 2020·Frontiers in Neurology·Alain Nicolas, Perrine M Ruby
Jan 21, 2017·The Journal of Nervous and Mental Disease·Mark A GreenbaumCraig S Rosen
Nov 24, 2020·Child and Adolescent Psychiatric Clinics of North America·Veronica FellmanSuchet Rao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.