Clonazepam use in pregnancy and the risk of malformations

Birth Defects Research. Part A, Clinical and Molecular Teratology
Angela E LinL B Holmes

Abstract

Clonazepam (Klonopin) is a benzodiazepine that has been used widely to treat seizures and conditions such as panic attacks and anxiety disorder. However, the current findings about its use in pregnancy are derived from limited studies of small sample size. Because it is commonly prescribed during pregnancy, more information about its safety is needed. The medical records of 28,565 infants were surveyed as part of a hospital-based malformation surveillance program to identify those who had been exposed prenatally to an anticonvulsant, including clonazepam. During a 32-month period, 166 anticonvulsant-exposed infants were identified; 52 had been exposed to clonazepam, 43 as monotherapy. A total of 33 (76.7%) of the monotherapy infants were exposed during the first trimester. One (3.0%) infant had dysmorphic features, growth retardation, and a heart malformation (tetralogy of Fallot). This study did not observe an increase in major malformations in births exposed to clonazepam monotherapy. However, this study is not large enough to have adequate power to determine whether or not the rate of major malformations is increased in clonazepam-exposed pregnancies. No increase has been identified in three other case series. Although the n...Continue Reading

References

Jan 1, 1989·Psychosomatics·L S CohenJ F Rosenbaum
Jan 5, 1989·The New England Journal of Medicine·K Nelson, L B Holmes
Apr 12, 2001·The New England Journal of Medicine·L B HolmesL M Ryan
May 8, 2001·Psychotherapy and Psychosomatics·L WeinstockJ F Rosenbaum
Jan 5, 2002·Psychiatric Services : a Journal of the American Psychiatric Association·Mohammad Masud IqbalThad Ryals
Feb 23, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Erika ErosJorn Olsen

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Citations

Apr 16, 2011·Current Treatment Options in Neurology·Laura Mantoan, Matthew Walker
Sep 9, 2008·Seminars in Neurology·Benzi M Kluger, Kimford J Meador
Jan 12, 2010·Human Reproduction Update·Marleen M H J van GelderNel Roeleveld
Jan 1, 2011·BMJ Case Reports·Sathiji NageshwaranMichael Morcos
Sep 11, 2009·Indian Journal of Psychiatry·Geetha DesaiPrabha S Chandra
Apr 26, 2013·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Miia ArtamaUNKNOWN Drug and Pregnancy Group
Apr 5, 2014·Thérapie·Marleen M H J van GelderNel Roeleveld
Oct 10, 2012·General Hospital Psychiatry·Cesario BellantuonoGiovanni Santone
Sep 4, 2015·Sleep Medicine Clinics·Chiara Prosperetti, Mauro Manconi
Apr 29, 2014·Parkinsonism & Related Disorders·Prachaya SrivanitchapoomMark Hallett
Jan 3, 2015·Sleep Medicine Reviews·Daniel L PicchiettiUNKNOWN International Restless Legs Syndrome Study Group (IRLSSG)
Dec 3, 2014·American Journal of Obstetrics and Gynecology·Michele L OkunBandana Saini
Oct 16, 2009·Seizure : the Journal of the British Epilepsy Association·Malin AlmgrenCatharina Lavebratt
Sep 28, 2020·Neurología : publicación oficial de la Sociedad Española de Neurología·R García-RamosP Mir

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