Cloned and transfected P2Y4 receptors: characterization of a suramin and PPADS-insensitive response to UTP

British Journal of Pharmacology
S J CharltonM R Boarder

Abstract

The P2Y family of receptors are G protein-coupled receptors for ATP, ADP, UTP and UDP. Recently several members of this family have been cloned, including the P2Y4, which is activated by UTP but not by ATP. In the present report, using receptors stably transfected into 1321N1 cells, we show that suramin acts as an antagonist at cloned P2Y1 and (less potently) P2Y2 receptors, but not at the cloned P2Y4 receptor. Furthermore, PPADS (pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid), a potent antagonist at the P2Y1 receptor, is a relatively inneffective antagonist at the cloned P2Y4 receptor. This work moves us closer to the goal of classifying the native P2Y receptors on the basis of agonist and antagonist profiles.

References

Nov 3, 1995·The Journal of Biological Chemistry·K ChangY Takuwa
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·C E ParrJ T Turner
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·C E ParrJ T Turner
Dec 29, 1995·The Journal of Biological Chemistry·T NguyenB F O'Dowd
Nov 1, 1995·British Journal of Pharmacology·C BrownM R Boarder
Feb 6, 1996·Biochemical and Biophysical Research Communications·T E WebbE A Barnard
May 15, 1996·Biochemical and Biophysical Research Communications·D CommuniJ M Boeynaems
Jun 1, 1996·British Journal of Pharmacology·S J CharltonM R Boarder

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Citations

Feb 13, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·M E DockrellB M Hendry
Apr 6, 2001·European Journal of Pharmacology·N Suarez-HuertaB Robaye
Nov 22, 1997·European Journal of Pharmacology·T MatsumotoS Chiba
Aug 11, 1998·European Journal of Pharmacology·G J McLarenC Kennedy
May 19, 1998·Trends in Pharmacological Sciences·M R Boarder, S M Hourani
Nov 7, 2000·Neuroscience Letters·K Sak
Jun 1, 1997·Current Opinion in Neurobiology·R A North, E A Barnard
Mar 10, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·G FroldiL Caparrotta
Jun 18, 1998·British Journal of Pharmacology·G J McLarenC Kennedy
Oct 24, 1998·British Journal of Pharmacology·A R ConantA W Simpson
Feb 22, 2000·British Journal of Pharmacology·C J DixonA K Green
Jan 30, 2002·British Journal of Pharmacology·Robert A Kaiser, Iain L O Buxton
Oct 17, 2002·British Journal of Pharmacology·K ChootipC Kennedy
Mar 26, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hui WangJames J Galligan
Jul 3, 2004·American Journal of Respiratory Cell and Molecular Biology·Philip A KempAlan D Jackson
Nov 4, 2005·Cell Communication and Signaling : CCS·Daniel C MarcusPhiline Wangemann
Nov 6, 2009·Cellular and Molecular Bioengineering·Diana YuGabriel A Silva
Nov 1, 2015·Neuropharmacology·Ivar von Kügelgen, Kristina Hoffmann
Jun 15, 2007·British Journal of Pharmacology·H JiangJ C McGiff
Nov 1, 2005·Pharmacology & Therapeutics·Ivar von Kügelgen
Jul 15, 2016·Journal of Medicinal Chemistry·Sean ConroyMichael J Stocks
Jan 25, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R Sartorello, C R S Garcia
Jul 3, 2003·Journal of Lipid Research·Celine LuquainAndrew J Morris
Nov 5, 2003·British Journal of Pharmacology·Rajendra KumariMichael R Boarder
Apr 22, 2004·The Journal of Biological Chemistry·Jun Hee KimSung Joon Kim
Dec 16, 1998·FEBS Letters·K SakJ Järv
May 5, 2007·Journal of Cellular Physiology·Fei MengYuchun Gu
Apr 6, 2002·Circulation Research·Xavier PilloisAlain-Pierre Gadeau
May 26, 2006·American Journal of Physiology. Cell Physiology·Kevin P MonaghanKenton M Sanders
Sep 11, 2003·The Journal of Pharmacology and Experimental Therapeutics·Gloria QueirozJorge Gonçalves
Aug 24, 2004·Molecular Pharmacology·Steven J EnnionElizabeth P Seward
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N L'HeureuxR Andriantsitohaina

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