PMID: 6970897Mar 5, 1981Paper

Clones of helper T cells mediate antigen-specific, H-2-restricted DTH

Nature
A T BianchiM H Schreier

Abstract

It is now well established that in the mouse, helper T cells and killer T cells are two distinct thymus-derived lymphocyte subpopulations, differing from each other in Lyt phenotype and H-2 restriction, among other parameters. Helper T cells are Lyt-1+ and their action in immune responses involves restriction at the H-2I region of the major histocompatibility complex (MHC). Killer cells, on the other hand, are Lyt-23+ and their activity is restricted by H-2K/D (refs 1, 3). In most instances, T cells mediating delayed-type hypersensitivity (DTH) responses share the Lyt phenotype and H-2 restriction of the helper T cell. This raises the question of whether or not helper activity and DTH can be mediated by the same activated T cell. Arguments for both views have been reported. We analysed this question using clones of specific helper T cells, which were obtained by long-term culture in vitro of in vivo primed T cells, followed by single-cell cloning. Here we show that these clones of helper T cells mediate antigen-specific and fully H-2-restricted DTH. The restricting element lies to the left of the I-B region in genetic maps of the mouse MHC.

References

Jul 1, 1978·The Journal of Experimental Medicine·P H Lagrange, G B Mackaness
Jan 1, 1979·International Archives of Allergy and Applied Immunology·F Smith, J F Miller
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J F MillerJ Gamble
Jul 1, 1976·The Journal of Experimental Medicine·M A VadasA M Whitelaw
Oct 1, 1972·Cellular Immunology·S M PhillipsJ P Merrill
Oct 1, 1972·Cellular Immunology·S M PhillipsJ P Merrill
Jul 1, 1974·Progress in Cardiovascular Diseases·H GavrasJ H Laragh
Jan 1, 1980·International Archives of Allergy and Applied Immunology·M H Schreier, R Tees
Jan 1, 1980·The Journal of Experimental Medicine·M H SchreierF Melchers

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Citations

Feb 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J M Lemire, J S Adams
May 1, 1985·Clinical Reviews in Allergy·W J MetzgerH B Richerson
Feb 25, 1983·Journal of Immunological Methods·T M Folks, K W Sell
Apr 9, 1990·Mechanisms of Ageing and Development·C VissingaJ Rozing
Apr 1, 1986·Clinics in Dermatology·S M Breathnach
May 1, 1989·Research in Immunology·M W KieranA Israel
Mar 1, 1982·Immunobiology·M H SchreierM J van Zwieten
Feb 22, 2001·Free Radical Biology & Medicine·J FuchsM Podda
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T M KündigR M Zinkernagel
Jul 1, 1988·Annals of the Rheumatic Diseases·R A KayR S Pumphrey
Nov 1, 1986·Immunological Investigations·C WeyandC G Fathman
Dec 1, 1984·Immunobiology·D R Katz
Apr 1, 1995·Journal of the American Academy of Dermatology·R S Kalish
Feb 1, 1989·European Journal of Immunology·S R CardingK Bottomly
Dec 1, 1981·Scandinavian Journal of Immunology·J C Howard, G W Butcher
Apr 15, 1983·Cellular Immunology·J BurnsR P Lisak
Feb 4, 1982·Nature·E Simpson
Jan 1, 1985·Critical Reviews in Clinical Laboratory Sciences·H Bril, R Benner
May 1, 1984·Journal of Virology·H C Ertl, R W Finberg

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