Clones of serogroup B Neisseria meningitidis causing systemic disease in The Netherlands, 1958-1986

The Journal of Infectious Diseases
D A CaugantL O Frøholm

Abstract

Serogroup B isolates of Neisseria meningitidis recovered from 278 patients with systemic disease in the Netherlands between 1958 and 1986 were analyzed with respect to serotype and multilocus enzyme genotype. Of the isolates, 28% were serotype 2b and 53% were neither serotypeable nor serosubtypeable. There were 145 distinct multilocus genotypes (electrophoretic types, ETs), with up to 31 isolates belonging to the same ET. Temporal changes in the genotypic composition of meningococcal populations in the Netherlands were demonstrated by the recent occurrence of disease caused by three clone lineages, I, III, and VI, that were not found before 1975. The epidemic of 1966-1967 and the hyperendemic wave of 1972 were caused, in large part, by two closely related but distinct clones of serotype 2b isolates, ET-11 and ET-17, respectively. Deviations in male-to-female ratio and age distribution of patients were observed for disease caused by isolates of individual clone lineages.

Citations

Nov 11, 1999·Parasitology Today·S Gupta, R M Anderson
Apr 5, 2001·Trends in Microbiology·S Gupta, M C Maiden
Aug 1, 1994·Epidemiology and Infection·D E YakubuT H Pennington
Apr 1, 1996·Epidemiology and Infection·M GuibourdencheD A Caugant
Feb 24, 2006·Epidemiology and Infection·K H Dyet, D R Martin
Jul 23, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·D A Caugant
Jan 19, 2006·Clinical Microbiology Reviews·Lee H Harrison
Feb 23, 2007·Journal of Clinical Microbiology·Ana Paula Silva de LemosClaudio Tavares Sacchi
Apr 9, 2004·Journal of Clinical Microbiology·Kristin H DyetDiana R Martin
Mar 6, 2010·Emerging Infectious Diseases·Johannes EliasArie van der Ende
May 12, 2009·Vaccine·Yanwen LiDlawer A A Ala'aldeen
Feb 28, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Marleen Van LooverenHerman Goossens
Oct 2, 1998·Revista Do Instituto De Medicina Tropical De São Paulo·C T SacchiL W Mayer
Jul 1, 1995·Revista Do Instituto De Medicina Tropical De São Paulo·C T SacchiA Sperb
Dec 20, 2005·Expert Review of Molecular Diagnostics·Mathew A Diggle, Stuart C Clarke
May 19, 2001·Canadian Journal of Microbiology·F E Ashton, D A Caugant
Jul 3, 1999·Clinical and Diagnostic Laboratory Immunology·E WedegeW D Zollinger
May 1, 1992·Journal of Clinical Microbiology·C T SacchiC E Melles
May 1, 1995·Clinical and Diagnostic Laboratory Immunology·E WedegeD A Caugant

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.