Clones of Streptococcus pneumoniae isolated from nasopharyngeal carriage and invasive disease in young children in central Tennessee

The Journal of Infectious Diseases
D A RobinsonSusan K Hollingshead

Abstract

To determine whether nasopharyngeal carriage isolates of Streptococcus pneumoniae are of the same genetic background as isolates that caused invasive disease in one community, IS1167 and boxA genotypes were obtained for 182 pneumococcal isolates from children living in central Tennessee. The isolates represented 70 combined IS1167-boxA genotypes. The genotypic diversity of the invasive isolates was significantly less than that of the total population (P=.003). Most of the carriage isolates belonged to genotypes unique to carriage, whereas most of the invasive isolates belonged to genotypes common to carriage and disease (P=.02). Monte Carlo simulations showed a greater number of genotypes unique to carriage than can be explained by chance (P<.05 in all cases). Two genotypes were identified by multilocus sequence typing as members of globally disseminated clones, and one such genotype that was strictly carriage in this sample caused disease in other studies. Thus, clones can have different propensities for carriage and invasion.

Citations

Feb 19, 2002·International Journal of Antimicrobial Agents·Helena K Parsons, David H Dockrell
Oct 26, 2002·Journal of Bacteriology·D Ashley RobinsonSusan K Hollingshead
May 20, 2003·Journal of Bacteriology·Edward J FeilNicholas P J Day
Aug 9, 2003·Journal of Clinical Microbiology·Ana Lucia Sampaio Sgambatti de AndradeJose Luis Di Fabio
Aug 2, 2008·The Journal of Infection·Joice Neves ReisAlbert I Ko
Sep 5, 2007·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Caroline A ObertCarlos J Orihuela
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ravichandran PalaniappanJames W Lillard

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