Clonic perseveration following thalamofrontal disconnection: a distinctive movement disorder

Movement Disorders : Official Journal of the Movement Disorder Society
V S FungL Davies

Abstract

We describe four patients who developed asymmetrical, rhythmic, stereotyped, and repetitive movements of the upper and lower limbs hours to days after infarction that involved the thalamus and/or basal ganglia. The movements appeared to occur spontaneously and were initially labeled as focal motor seizures, ballism, or tremor; they could however, be induced by passive movement of the limbs. The movements most commonly observed were scratching or rubbing movements of the hands that were of such persistence as to cause trauma to the skin; in the lower limbs, the heel was run up and down the bed sheet, often until it bled. The movements were part of a syndrome characterised initially by a reduced level of consciousness and followed by aspontaneity, usually with mutism and frontal release signs. One patient who had relatively preserved cognition and language repeated words or phrases again and again when encouraged to speak, but had no difficulty changing responses appropriately to different cues. In drawing, he overwrote each figure but could change the figure on command. The distinctive movement disorder in these patients was due to clonic perseveration. We suggest that clonic perseveration results from disconnection of prefronta...Continue Reading

References

Feb 1, 1992·Stroke; a Journal of Cerebral Circulation·J S Kim
Jul 1, 1990·Trends in Neurosciences·G E Alexander, M D Crutcher
Jan 1, 1991·Movement Disorders : Official Journal of the Movement Disorder Society·D M MaraganoreC D Marsden
Jan 1, 1986·Annual Review of Neuroscience·G E AlexanderP L Strick
Jun 1, 1988·Neurology·J BogousslavskyA Uske
Nov 1, 1987·Neurology·J Sandson, M L Albert
Dec 1, 1986·Journal of Clinical and Experimental Neuropsychology·E Goldberg
Jan 1, 1970·Brain : a Journal of Neurology·B ShahaniC W Whitty
Sep 1, 1968·Brain : a Journal of Neurology·A J Hudson
Jan 1, 1966·The British Journal of Psychiatry : the Journal of Mental Science·T Freeman, C E Gathercole
Jan 1, 1984·Neuropsychologia·J Sandson, M L Albert
Aug 1, 1981·Annals of Neurology·P CastaigneO Lyon-Caen
Jan 1, 1994·Fundamental & Clinical Pharmacology·R A Weeks, D J Brooks
Aug 1, 1994·Brain : a Journal of Neurology·C D Marsden, J A Obeso
Sep 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·M S Lee, C D Marsden
Aug 1, 1993·Archives of Neurology·J L Cummings
Apr 1, 1993·Movement Disorders : Official Journal of the Movement Disorder Society·A Ferbert, M Gerwig
Mar 1, 1964·Brain : a Journal of Neurology·D SUMNER
Mar 1, 1965·Brain : a Journal of Neurology·A R LURIA

❮ Previous
Next ❯

Citations

Sep 24, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·T RosolacciP Dobbelaere
Mar 24, 2004·Parkinsonism & Related Disorders·Hideto MiwaTomoyoshi Kondo
Oct 7, 2005·Journal of Clinical and Experimental Neuropsychology·Katherine L PossinJennifer D Davis
Mar 20, 2009·Age and Ageing·Anita Chittaranjan ShettyPaul O'Mahony
Nov 20, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·J S SnowdenD Neary
May 1, 1999·Journal of Neurosurgery·J K KraussN Godoy
May 7, 2011·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Martin KrauseJohn G L Morris
Nov 14, 2006·Journal of the Neurological Sciences·Y OnoK Abe
Aug 27, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Shekeeb S MohammadRussell C Dale
Nov 30, 2010·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Lieve De WittePeter Mariën
May 23, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·José Luiz PedrosoElias Knobel
Jun 6, 2018·European Neurology·Navnika Gupta, Sanjay Pandey
Oct 5, 2010·Aging Clinical and Experimental Research·Malcolm WellsManuel Montero Odasso

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.