Clonidine added to the anesthetic solution enhances analgesia and improves oxygenation after intercostal nerve block for thoracotomy

Anesthesia and Analgesia
E M TschernkoW Haider

Abstract

We evaluated the effect of adding clonidine to bupivacaine on postoperative pain control and oxygenation after intercostal nerve blockade (ICB) for thoracotomy, and attempted to distinguish a systemic from a local effect of clonidine. ICB with 2 mg/kg 0.5% bupivacaine was performed in 36 patients undergoing thoracotomy. Patients were randomized to one of three groups: 1) a control group that received bupivacaine with saline for ICB and an IM injection of saline, 2) an IM group that received bupivacaine with saline for ICB and an IM injection of 2 micrograms/kg clonidine, and 3) a block group that received bupivacaine with 2 micrograms/kg clonidine for ICB and an IM injection of saline. Blood gases, visual analog scale (VAS) scores, and analgesic demand were determined hourly for 8 h after arrival in the postoperative care unit (PCU). Patients in the block group had significantly lower VAS scores, higher arterial oxygen tension, and lower analgesic demand for the first 4 h in the PCU, compared with the two other groups. No difference was noted thereafter. We conclude that the addition of clonidine to bupivacaine for ICB leads to a short-term effect enhancing postoperative pain control and improving arterial oxygenation, probably...Continue Reading

References

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Citations

Feb 20, 2010·European Journal of Drug Metabolism and Pharmacokinetics·E TigkaC Tesseromatis
Apr 12, 2002·Journal of Clinical Anesthesia·Marta F G BarioniNewton L Pereira
Jun 27, 2003·Journal of Cardiothoracic and Vascular Anesthesia·Katherine P Grichnik, Steven E Hill
Nov 9, 2010·The Veterinary Clinics of North America. Equine Practice·Alexander Valverde
Jun 15, 2007·Veterinary Anaesthesia and Analgesia·Leigh A Lamont, Kip A Lemke
Oct 25, 2000·Anesthesiology·T Kamibayashi, M Maze

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