Clonidine: an alternative to benzodiazepines for premedication in children

Current Opinion in Anaesthesiology
H T BergendahlStaffan Eksborg

Abstract

The aim of this review is to summarize the use of clonidine for paediatric premedication and to make a comparison with benzodiazepines. A routine clonidine premedication protocol is also presented. In the US 50% of young children undergoing surgery receive premedication and midazolam is the most frequently used drug. The number of trials that compare midazolam with active controls are few and this premedicant is not adequately validated. Clonidine is still used as premedication in a small number of centres but the literature on paediatric use of clonidine is steadily growing. A recent review article has concluded that the use of clonidine does enhance the quality of perioperative management in infants and children and more recent publications support the use of clonidine for premedication. Its effect on the circulation is mild but routine atropine administration is recommended. Contraindications to the use of clonidine are few. Apart from a general overview on the effects of clonidine this article will also summarise the published trials that have compared clonidine with benzodiazepines for premedication in children. Midazolam the most commonly used drug for paediatric premedication worldwide. Despite having a number of benefic...Continue Reading

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Citations

Mar 14, 2012·Saudi Journal of Anaesthesia·Senthil Gopalakrishnan, Joseph D Tobias
Aug 26, 2010·Paediatric Anaesthesia·Peter LarssonBrian J Anderson
Jan 21, 2010·Acta Anaesthesiologica Scandinavica·S DahmaniI Murat
Dec 18, 2009·Paediatric Anaesthesia·Vivian Man Ying Yuen
Jun 25, 2014·Paediatric Anaesthesia·Lee BlackburnBrian J Anderson
May 20, 2015·Der Anaesthesist·V LehmannR K Ellerkmann
May 9, 2019·Journal of Dental Anesthesia and Pain Medicine·Vedangi MohiteNilesh Rathi
Sep 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Haitham AlRabiahGamal A E Mostafa
Mar 27, 2020·Korean journal of anesthesiology·Seok-Jin Lee, Tae-Yun Sung

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